Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | B2RXC2 | isoform inositol 1,4,5-trisphosphate 3-kinase B | - |
Synonyms | Comment | Organism |
---|---|---|
inositol 1,4,5-trisphosphate 3-kinase B | - |
Mus musculus |
Itpkb | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform inositol 1,4,5-trisphosphate 3-kinase B is important for the control of Bim protein expression and B cell survival rather than for the control of B cell development from one stage to another. B cell receptor transgenic inositol 1,4,5-trisphosphate 3-kinase B-/- B cells exhibit an anergic phenotype with the notable exception of their enhanced antigen-induced calcium signalling. On a deleting H2-Kb genetic background, inositol 1,4,5-trisphosphate 3-kinase B is not essential for B cell receptor editing or negative selection | Mus musculus |