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Literature summary for 2.7.1.127 extracted from

  • Nalaskowski, M.M.; Fliegert, R.; Ernst, O.; Brehm, M.A.; Fanick, W.; Windhorst, S.; Lin, H.; Giehler, S.; Hein, J.; Lin, Y.N.; Mayr, G.W.
    Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope (2011), J. Biol. Chem., 286, 4500-4510.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus sequence of isoform inositol-trisphosphate 3-kinase B contains an exportin 1-dependent nuclear export signal, 134LQRELQNVQV, and the amino acids responsible for nuclear localization 129RKLR. These two targeting domains regulate the amount of nuclear IP3KB in cells. The localization of isoform inositol-trisphosphate 3-kinase B at the plasma membrane is due to its binding to cortical actin structures. All three of these targeting activities reside in one small polypeptide segment, amino acids 104-165, which acts as a multitargeting domain. In rapidly growing H1299 cells, inositol-trisphosphate 3-kinase B is specifically enriched at nuclear invaginations extending perpendicularly between the apical and basal surface of the nucleus of these flat cells Homo sapiens 5634
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plasma membrane the localization of isoform inositol-trisphosphate 3-kinase B at the plasma membrane is due to its binding to cortical actin structures Homo sapiens 5886
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Organism

Organism UniProt Comment Textmining
Homo sapiens P27987 isoform inositol-trisphosphate 3-kinase B
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