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Literature summary for 2.7.1.134 extracted from

  • Wilson, M.P.; Hugge, C.; Bielinska, M.; Nicholas, P.; Majerus, P.W.; Wilson, D.B.
    Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase (2009), Proc. Natl. Acad. Sci. USA, 106, 9831-9835.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
a recombinant fusion protein between GST and residues 124-311 of human ITPK1 is prepared in Escherichia coli to produce antibodies for Western blotting Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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C57Bl6 mice
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Mus musculus C57BL6
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C57Bl6 mice
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Purification (Commentary)

Purification (Comment) Organism
by chromatography on a glutathione agarose column Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
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Mus musculus
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cervical ganglion
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Mus musculus
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skeletal muscle
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Mus musculus
-

Synonyms

Synonyms Comment Organism
inositol 1,3,4-trisphosphate 5/6-kinase
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Mus musculus
ITPK1
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Mus musculus

General Information

General Information Comment Organism
malfunction generation of a mouse strain harboring a beta-galactosidase gene trap cassette in the second intron of the Itpk1 gene leads to animals, homozygous for this gene trap, which are viable, fertile, they produce less ITPK1 protein than wild-type and heterozygous animals, embryos resulting from homozygous matings uncovered neural tube defects in some animals and axial skeletal defects or growth retardation in others Mus musculus
physiological function key regulatory enzyme at the branch point for the synthesis of inositol hexakisphosphate, an intracellular signaling molecule implicated in the regulation of ion channels, endocytosis, exocytosis, transcription, DNA repair, and RNA export from the nucleus Mus musculus