Literature summary for 2.7.1.136 extracted from

Taniguchi, K.; Nakamura, A.; Tsurubuchi, K.; Ishii, A.; O'Hara, K.; Sawai, T.
Identification of functional amino acids in the macrolide 2'-phosphotransferase II (1999), Antimicrob. Agents Chemother., 43, 2063-2065.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	potassium chloride enhances reactivity, it is added in the reaction mixture at 0.06 M	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	macrolide 2'-phosphotransferase type II, similar levels of activity with 14-member ring macrolides or 16-member ring macrolides, strain CU1 or BM 2506	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + clarithromycin	46-55% activity with respect to oleandomycin for strain CU1, 17% activity with respect to oleandomycin for strain BM 2506	Escherichia coli	?	-	?
ATP + josamycin	75-95% activity with respect to oleandomycin for strain CU1, 96% activity with respect to oleandomycin for strain BM 2506	Escherichia coli	?	-	?
ATP + oleandomycin	-	Escherichia coli	ADP + oleandomycin 2'-O-phosphate	-	?
ATP + spiramycin	57-75% activity with respect to oleandomycin for strain CU1, 26% activity with respect to oleandomycin for strain BM 2506	Escherichia coli	ADP + spiramycin 2'-O-phosphate	-	?

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Release 2023.1 (January 2023)