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Literature summary for 2.7.1.137 extracted from

  • Ruiz-Larrea, F.; Vicendo, P.; Yaish, P.; End, P.; Panayotou, G.; Fry, M.J.; Morgan, S.J.; Thompson, A.; Parker, P.J.; Waterfield, M.D.
    Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex (1993), Biochem. J., 290, 609-616.
No PubMed abstract available
Search for more literature for 2.7.1.137

Inhibitors

Inhibitors Comment Organism Structure
5'-p-fluorosulfonylbenzoyladenosine
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Bos taurus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
 1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE Bos taurus
85000
-
 1 * 85000 + 1 * 110000 Bos taurus
110000
-
 1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE Bos taurus
110000
-
 1 * 85000 + 1 * 110000 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus receptor linked enzyme may generate a second-messenger signal ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein purified enzyme complex is highly phosphorylated on both subunits, dephosphorylation generates a deactivated complex Bos taurus
phosphoprotein highly phosphorylated on both p85a and p110 subunits, and dephosphorylation generates a deactivated complex, indicating that phosphorylation is an important covalent modification of the complex and may modulate PtdIns 3-kinase activity Bos taurus

Purification (Commentary)

Purification (Comment) Organism
large scale Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
 Bos taurus ADP + phosphatidylinositol 3-phosphate
-
 ?
additional information receptor linked enzyme may generate a second-messenger signal Bos taurus ?
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE Bos taurus
dimer 1 * 85000 + 1 * 110000 Bos taurus
More the 110000 Da subunit contains an ATP-binding site Bos taurus

Synonyms

Synonyms Comment Organism
receptor-linked phosphatidylinositol 3-kinase
-
 Bos taurus