Activating Compound | Comment | Organism | Structure |
---|---|---|---|
G-protein betagamma subunits | betagamma subunits of heterotrimeric G-protein | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant HA-tagged PI3K isozyme gamma and of subunit p110 in COS-7 cells, stimulation of the protein kinases Erk, JNK, and PKB | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | no JNK stimulation in enzyme-deficient mutant cells or by enzyme p110delta mutants | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | the enzyme binds to the plasma membrane to get access to its lipid substrate phosphatidylinositol-4,5-bisphosphate, membrane binding via the C-terminal CAAX domain | Mus musculus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphatidylinositol-4,5-bisphosphate | Mus musculus | - |
ADP + phosphatidylinositol-3,4,5-trisphosphate | - |
? | |
ATP + phosphatidylinositol-4-phosphate | Mus musculus | - |
ADP + phosphatidylinositol-3,4-bisphosphate | - |
? | |
additional information | Mus musculus | the isozyme gamma stimulates the protein kinases Erk, JNK, and PKB and thus plays a role in cellular signaling, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozyme gamma | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme performs autophosphorylation at Ser1039 of the catalytic p110delta subunit | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphatidylinositol-4,5-bisphosphate | - |
Mus musculus | ADP + phosphatidylinositol-3,4,5-trisphosphate | - |
? | |
ATP + phosphatidylinositol-4-phosphate | - |
Mus musculus | ADP + phosphatidylinositol-3,4-bisphosphate | - |
? | |
additional information | the isozyme gamma stimulates the protein kinases Erk, JNK, and PKB and thus plays a role in cellular signaling, overview | Mus musculus | ? | - |
? | |
additional information | the enzyme shows both lipid and protein kinase activity | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphoinositide 3-kinase gamma | - |
Mus musculus |
PI3K | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
kinase assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
kinase assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |