Literature summary for 2.7.1.137 extracted from

Zhang, X.; Mi, J.; Wetsel, W.C.; Davidson, C.; Xiong, X.; Chen, Q.; Ellinwood, E.H.; Lee, T.H.
PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity (2006), Biochem. Biophys. Res. Commun., 340, 1144-1150.

Search for more literature for 2.7.1.137

Application

Application	Comment	Organism
medicine	selective enhancement of the PI3K activity in the nuclear accumbens shell may be one of key alterations underlying the long-term cocaine sensitization. To the extent cocaine sensitization is an important factor in human cocaine abuse, pharmacological interventions targeted toward the NAc shell PI3K alteration may be useful in cocaine abuse treatment	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	nuclear accumbens shell and core, prefrontal cortex	Rattus norvegicus	-
nucleus accumbens	shell and core. Cocaine sensitization decreases PI3K activity in nuclear accumbens core. The changes are not normalized following the reversal of cocaine-sensitization. Cocaine-sensitized animals exhibited increased PI3K activity in the nuclear accumbens shell, and this increase is reversed by combined pergolide/ondansetron treatment. Selective enhancement of the PI3K activity in the NAc shell may be one of key alterations underlying the long-term cocaine sensitization	Rattus norvegicus	-
prefrontal cortex	cocaine sensitization increases PI3K activity. The changes are not normalized following the reversal of cocaine-sensitization	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
phosphatidylinositol 3-kinase	-	Homo sapiens
phosphatidylinositol 3-kinase	-	Rattus norvegicus
PI3K	-	Homo sapiens
PI3K	-	Rattus norvegicus

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Release 2023.1 (January 2023)