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Literature summary for 2.7.1.137 extracted from

  • Tang, C.H.; Lu, D.Y.; Yang, R.S.; Tsai, H.Y.; Kao, M.C.; Fu, W.M.; Chen, Y.F.
    Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia (2007), J. Immunol., 179, 1292-1302.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus leptin activates leptin receptor and results in the actvation of insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300, leading to up-regulation of IL-6 expression ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
BV-2 cell microglial cell Mus musculus
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microglia
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information leptin activates leptin receptor and results in the actvation of insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300, leading to up-regulation of IL-6 expression Mus musculus ?
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 ?