Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.137 extracted from

  • Liu, H.; Li, H.; Guo, L.; Li, M.; Li, C.; Wang, S.; Jiang, W.; Liu, X.; McNutt, M.A.; Li, G.
    Mechanisms involved in phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes (2010), Biochem. Pharmacol., 79, 516-523.
    View publication on PubMed
Search for more literature for 2.7.1.137

Activating Compound

Activating Compound Comment Organism Structure
morphine morphine treatment enhances the level of phosphorylated, rather than unphosphorylated, PI3K and AKT, which are synchronously recruited to membrane. Levels of PTEN and p53, which are negative regulators of these signal molecules, are reduced, and as a result, the interaction between PTEN and p53 is completely interrupted Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002 i.e. [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] Homo sapiens
naloxone
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
heterodimer PI3K is a heterodimer composed of a p85 regulatory subunit and a p110 catalytic subunit Homo sapiens

Synonyms

Synonyms Comment Organism
PI3K
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function role of PI3K/AKT signaling in expression of the MOR gene in CEM x 174 cells. Phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes, mechanisms, overview Homo sapiens