Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PI3K-dependent phosphorylation of Akt1 activates it to phosphorylate p40phox and p40phox-p67phox complex, causing platelet-activating factor-mediated endosome formation required for the membrane translocation of p40phox and p67phox in neutrophils. Platelet-activating factor elicites an interaction between PI3K and p40phox and to a lesser extent between PI3K and phosphorylated p40phox, pathway overview | Homo sapiens |