Literature summary for 2.7.1.137 extracted from

McLaughlin, N.J.; Banerjee, A.; Khan, S.Y.; Lieber, J.L.; Kelher, M.R.; Gamboni-Robertson, F.; Sheppard, F.R.; Moore, E.E.; Mierau, G.W.; Elzi, D.J.; Silliman, C.C.
Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils (2008), J. Immunol., 180, 8192-8203.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PI3K	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	PI3K-dependent phosphorylation of Akt1 activates it to phosphorylate p40phox and p40phox-p67phox complex, causing platelet-activating factor-mediated endosome formation required for the membrane translocation of p40phox and p67phox in neutrophils. Platelet-activating factor elicites an interaction between PI3K and p40phox and to a lesser extent between PI3K and phosphorylated p40phox, pathway overview	Homo sapiens

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Release 2023.1 (January 2023)