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Literature summary for 2.7.1.137 extracted from

  • Hu, J.; Xia, X.; Cheng, A.; Wang, G.; Luo, X.; Reed, M.F.; Fojo, T.; Oetting, A.; Gong, J.; Yen, P.M.
    A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy (2008), Mol. Cancer Ther., 7, 3719-3728.
    View publication on PubMed

Application

Application Comment Organism
drug development the regulatory subunit p55PIK of PI3K is a trget for inhibitor development in cancer therapy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
peptide N24 a peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase, N24, regulatory subunit acts as inhibitor in cancer therapy, it blocks cell proliferation and induces cell cycle arrest in all cancer cell lines tested. Modeling of mechanisms of Rb-dependent and Rb-independent cell cycle arrest by N24 peptide, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PI3K specifically interacts with retinoblastoma protein through the unique NH2 terminus of its regulatory subunit p55PIK, peptide N24. This interaction is critical for cell proliferation and cell cycle progression ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
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Homo sapiens
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FTC-133 cell primary tumor cell line Homo sapiens
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FTC-236 cell nodal metastasis cell line Homo sapiens
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HT-29 cell
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Homo sapiens
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thyroid cancer cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PI3K specifically interacts with retinoblastoma protein through the unique NH2 terminus of its regulatory subunit p55PIK, peptide N24. This interaction is critical for cell proliferation and cell cycle progression Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
PI3K
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Homo sapiens

General Information

General Information Comment Organism
physiological function PI3K specifically interacts with retinoblastoma protein through the unique NH2 terminus of its regulatory subunit p55PIK, N24, which is critical for cell proliferation and cell cycle progression Homo sapiens