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Literature summary for 2.7.1.138 extracted from

  • Boath, A.; Graf, C.; Lidome, E.; Ullrich, T.; Nussbaumer, P.; Bornancin, F.
    Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin (2008), J. Biol. Chem., 283, 8517-8526.
    View publication on PubMed
Search for more literature for 2.7.1.138

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus ceramide is transported to the Golgi complex for phosphorylation by ceramide kinase Mus musculus 5794
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Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the intracellular calcium chelator BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid) decreases ceramide 1-phosphate formation by almost 100%, demonstrating the total dependence of ceramide kinase on Ca2+-ions Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + ATP Mus musculus ceramide 1-phosphate is a sphingolipid that participates in cell signaling, but ceramide kinase is not the only source of ceramide 1-phosphate ceramide 1-phosphate + ADP
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
femur extraction of bone marrow and preparation of macrophages Mus musculus
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macrophage bone marrow-derived macrophage, BMDM Mus musculus
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primary cell bone marrow-derived macrophage, BMDM Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + ATP
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 Mus musculus ceramide 1-phosphate + ADP
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ceramide + ATP ceramide 1-phosphate is a sphingolipid that participates in cell signaling, but ceramide kinase is not the only source of ceramide 1-phosphate Mus musculus ceramide 1-phosphate + ADP
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 ?
N-((4-(4,4-difluoro-5-(2-thienyl)-4-bora-3alpha,4alpha-diaza-s-indacene-3-yl)phenoxy)acetyl)sphingosine + ATP TRB-ceramide Mus musculus N-((4-(4,4-difluoro-5- (2-thienyl)-4- bora-3a,4a-diaza-s-indacene-3-yl)phenoxy)acetyl)sphingosine 1-phosphate + ADP
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N-(5-(5,7-dimethyl-BODIPY)-L-pentanoyl)-D-erythrosphingosine + ATP DMB-C5 ceramide Mus musculus N-(5-(5,7-dimethyl-BODIPY)-L-pentanoyl)-D-erythrosphingosine 1-phosphate + ADP
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N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine + ATP NBD-Cer, NBD-C6 ceramide Mus musculus N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine 1-phosphate + ADP
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Synonyms

Synonyms Comment Organism
CERK
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 Mus musculus