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Literature summary for 2.7.1.138 extracted from

  • Murakami, M.; Ito, H.; Hagiwara, K.; Yoshida, K.; Sobue, S.; Ichihara, M.; Takagi, A.; Kojima, T.; Tanaka, K.; Tamiya-Koizumi, K.; Kyogashima, M.; Suzuki, M.; Banno, Y.; Nozawa, Y.; Murate, T.
    ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: The role of COUP-TFI (2010), J. Neurochem., 112, 511-520.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
all-trans retinoic acid inhibits ceramide kinase transkription in neuroblastoma cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Homo sapiens
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TCT0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity is decreased during all-trans retinoic acid-induced neuronal differentiation of SH-SY5Y cells, all-trans retinoic acid reduces CERK protein and mRNA level in a time- and concentration-dependent manner, all-trans retinoic acid reduces cellular enzyme product ceramide 1-phosphate to 60% of control cells Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
 Homo sapiens ADP + ceramide 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ceramide kinase
-
 Homo sapiens
CERK
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens all-trans retinoic acid inhibits ceramide kinase transkription during neuronal differentiation of a human neuroblastoma cell line SH-SY5Y, inhibition of the transcriptional activity of the 5'-promoter of ceramide kinase. Retinol does not reduce CERK protein and mRNA level down

General Information

General Information Comment Organism
physiological function enzyme plays an important role in cellular events such as cell growth and inflammation Homo sapiens