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Literature summary for 2.7.1.138 extracted from

  • Mitsutake, S.; Kumada, H.; Soga, M.; Hurue, Y.; Asanuma, F.; Nagira, M.; Deguchi, M.; Date, T.; Yokose, U.; Inagaki, Y.; Sugiura, M.; Kohama, T.; Igarashi, Y.
    Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell activation (2010), Prostaglandins Other Lipid Mediat., 93, 109-112.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(4aS,6aR,12aR,12bS)-10-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo(a)xanthene-8,11-dione ceramide kinase inhibitor K1, reduces the differences in degranulation observed between the bone marrow-derived mast cells from CERK-/- and wild-type mice in a dose-dependent manner Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K4Q7
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General Information

General Information Comment Organism
physiological function ceramide kinase might act as an modulator for mild and chronic activation of mast cells, thus increasing sensitivity to cytoplasmic Ca2+. CERK-/- mice are less prone to exhibiting a passive cutaneous anaphylactic shock-reaction compared to wild-type mice, the differences are not significant. In bone marrow-derived mast cells from CERK-/- mice activated by cross-linking antigen /IgE, low concentrations of Ag+ have a reduced effect on degranulation. Similarly, when the cells are activated with calcium ionophore to focus on the downstream signaling of Ca2+-elevation, only a low concentration of ionophore has a reduced effect on degranulation Mus musculus