Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4aS,6aR,12aR,12bS)-10-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo(a)xanthene-8,11-dione | ceramide kinase inhibitor K1, reduces the differences in degranulation observed between the bone marrow-derived mast cells from CERK-/- and wild-type mice in a dose-dependent manner | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8K4Q7 | - |
- |
General Information | Comment | Organism |
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physiological function | ceramide kinase might act as an modulator for mild and chronic activation of mast cells, thus increasing sensitivity to cytoplasmic Ca2+. CERK-/- mice are less prone to exhibiting a passive cutaneous anaphylactic shock-reaction compared to wild-type mice, the differences are not significant. In bone marrow-derived mast cells from CERK-/- mice activated by cross-linking antigen /IgE, low concentrations of Ag+ have a reduced effect on degranulation. Similarly, when the cells are activated with calcium ionophore to focus on the downstream signaling of Ca2+-elevation, only a low concentration of ionophore has a reduced effect on degranulation | Mus musculus |