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Literature summary for 2.7.1.14 extracted from

  • Kardon, T.; Stroobant, V.; Veiga-da-Cunha, M.; Schaftingen, E.V.
    Characterization of mammalian sedoheptulokinase and mechanism of formation of erythritol in sedoheptulokinase deficiency (2008), FEBS Lett., 582, 3330-3334.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli as a N-terminal fusion protein with a polyHis tag Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.19
-
sedoheptulose
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D5J6
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
128
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + altrose weak activity Mus musculus ?
-
?
ATP + mannoheptulose
-
Mus musculus ?
-
?
ATP + sedoheptulose
-
Mus musculus ADP + sedoheptulose 7-phosphate
-
?
additional information no activity with 2,7-sedoheptulosan, fructose, glucose, galactose (tested at up to 50 mM), erythritol and D-erythrose (tested at up to 10 mM) Mus musculus ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
115
-
sedoheptulose
-
Mus musculus