Literature summary for 2.7.1.140 extracted from

Chang, S.C.; Miller, A.L.; Feng, Y.; Wente, S.R.; Majerus, P.W.
The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase (2002), J. Biol. Chem., 277, 43836-43843.

Search for more literature for 2.7.1.140

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00011	-	myo-inositol-1,4,5-trisphosphate	pH 7.2, 37°C	Homo sapiens
0.00013	-	myo-inositol-1,3,4,5-tetrakisphosphate	pH 7.2, 37°C	Homo sapiens
0.0003	-	myo-inositol-1,3,4,6-tetrakisphosphate	pH 7.2, 37°C	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + myo-inositol 1,3,4,6-tetrakisphosphate	Homo sapiens	-	ADP + myo-inositol 1,3,4,5,6-pentakisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human EST	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant His-tagged enzyme, cobalt-affinity column	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + myo-inositol 1,3,4,5-tetrakisphosphate	approx. 2% of activity with 1,3,4,6-tetrakisphosphate	Homo sapiens	ADP + myo-inositol-1,3,4,5,6-pentakisphosphate	-	?
ATP + myo-inositol 1,3,4,6-tetrakisphosphate	-	Homo sapiens	ADP + myo-inositol 1,3,4,5,6-pentakisphosphate	-	?
ATP + myo-inositol 1,4,5-trisphosphate	approx. 50% of activity with 1D-myo-inositol 1,3,4,6-tetrakisphosphate, no activity with 1D-myo-inositol 1,3,4-trisphosphate	Homo sapiens	ADP + myo-inositol-1,3,4,5-tetrakisphosphate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)