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Literature summary for 2.7.1.145 extracted from

  • Solaroli, N.; Zheng, X.; Johansson, M.; Balzarini, J.; Karlsson, A.
    Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (2007), Mol. Pharmacol., 72, 1593-1598.
    View publication on PubMed
Search for more literature for 2.7.1.145

Application

Application Comment Organism
medicine mitochondrial targeting of Dm-dNK facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential Drosophila melanogaster
medicine mitochondrial targeting of multisubstrate nucleoside kinase facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
expression in a thymidine kinase 1-deficient osteosarcoma cell line. Mitochondrial targeting of Dm-dNK facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential Drosophila melanogaster
expression in osteosarcoma cell line Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information engineering of multisubstrate nucleoside kinase targeted to the mitochondrial matrix and expression in thymidine kinase-1 deficient osteosarcoma cell line. Although the total deoxythymidine phosphorylation activity is similar in cells expressing multisubstrate nullceoside kinase in the nucleus or in the mitochondria, the cells expressing the enzyme in the mitochondria show higher sensitivity to the antiproliferative activity of pyrimidine nucleoside analogs, such as (E)-5-(2-bromovinyl)-2-deoxyuridine, 5-bromo-2-deoxyuridine, and 5-fluoro-2-deoxyuridine. Cells expressing the mitochondrial enzyme have an increased incorporation of [3H]dThd into DNA, due to a higher [3H]dTTP specific activity of the total dTTP pool in the cells in which the enzyme is targeted to the mitochondria Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Drosophila melanogaster 5739
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Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
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Synonyms

Synonyms Comment Organism
Dm-dNK
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 Drosophila melanogaster
multisubstrate deoxyribonucleoside kinase
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 Drosophila melanogaster