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Literature summary for 2.7.1.145 extracted from
- Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli (2010), DNA Repair, 9, 153-160.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli K-12 cells | Drosophila melanogaster |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 2'-deoxynucleoside | dNK has a significant preference for pyrimidine deoxynucleosides over purine deoxynucleosides, but it does phosphorylate deoxyadenosine and deoxyguanosine at significant rates | Drosophila melanogaster | ADP + 2'-deoxynucleoside 5'-phosphate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dNK | - |
Drosophila melanogaster |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Drosophila melanogaster | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | dNK expression increases substantially sensitivity of cells to 5-aza-2'-deoxycytidine and 2'-deoxy-zebularine | Drosophila melanogaster |
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