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Literature summary for 2.7.1.147 extracted from

  • Kaminski, M.M.; Sauer, S.W.; Kaminski, M.; Opp, S.; Ruppert, T.; Grigaravinius, P.; Grudnik, P.; Groene, H.J.; Krammer, P.H.; Guelow, K.
    T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation (2012), Cell Rep., 2, 1300-1315.
    View publication on PubMed
Search for more literature for 2.7.1.147

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-
T-cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 T cell activation-induces upregulation in ADPGK activity Homo sapiens

Synonyms

Synonyms Comment Organism
ADP-dependent glucokinase
-
 Homo sapiens
ADPGK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction down-regulation of ADPGK or GPD2 abundance inhibits oxidative signal generation and induction of NF-kappaB-dependent gene expression, whereas over-expression of ADPGK potentiates them Homo sapiens
physiological function T cell activation-induced mitochondrial ROS production and NF-kappaB-driven gene expression depend on activation of ADPGK. ADPGK activation is accompanied by a rapid glucose uptake, downregulation of mitochondrial oxygen consumption, and deviation of glycolysis toward the glycerol-3-phosphate dehydrogenase shuttle Homo sapiens