Literature summary for 2.7.1.150 extracted from

Nicot, A.S.; Fares, H.; Payrastre, B.; Chisholm, A.D.; Labouesse, M.; Laporte, J.
The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans (2006), Mol. Biol. Cell, 17, 3062-3074.

Search for more literature for 2.7.1.150

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate	Caenorhabditis elegans	the main function of PPK-3 is to mediate membrane retrieval from matured lysosomes through regulation of PtdIns(3,5)P2. Complete loss of ppk-3 function induces developmental defects characterized by embryonic lethality, whereas partial loss of function leads to growth retardation. At the cellular level, ppk-3 mutants display a striking enlargement of vacuoles positive for lysosome-associated membrane protein 1 in different tissues	ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate	the main function of PPK-3 is to mediate membrane retrieval from matured lysosomes through regulation of PtdIns(3,5)P2. Complete loss of ppk-3 function induces developmental defects characterized by embryonic lethality, whereas partial loss of function leads to growth retardation. At the cellular level, ppk-3 mutants display a striking enlargement of vacuoles positive for lysosome-associated membrane protein 1 in different tissues	Caenorhabditis elegans	ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
phosphatidylinositol phosphate kinase 3	-	Caenorhabditis elegans
PIKfyve/Fab1p	-	Caenorhabditis elegans
PPK-3	-	Caenorhabditis elegans

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)