Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, no functional complementation of yeast mutant strains, expression of the N-terminally His-tagged enzyme in Escherichia coli strain BL21(DE3) | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens | |
0.00011 | - |
1D-myo-inositol 1,4,5-trisphosphate | recombinant enzyme, pH 7.2, 37°C | Homo sapiens | |
0.00013 | - |
1D-myo-inositol 1,3,4,5-tetrakisphosphate | recombinant enzyme, pH 7.2, 37°C | Homo sapiens | |
0.0003 | - |
1D-myo-inositol 1,3,4,6-tetrakisphosphate | recombinant enzyme, pH 7.2, 37°C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant N-terminally His-tagged enzyme from Escherichia coli strain BL21(DE3) by cobalt affinity chromatography | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | 43fold less active compared to 1D-myo-inositol 1,3,4,6-tetrakisphosphate | Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | preferred substrate | Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | 2fold less active compared to 1D-myo-inositol 1,3,4,6-tetrakisphosphate | Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | 2fold less active compared to 1D-myo-inositol 1,3,4,6-tetrakisphosphate | Homo sapiens | ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | - |
? | |
additional information | substrate specificity, product identification | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
1,3,4,6-tetrakisphosphate 5-kinase | - |
Homo sapiens |
inositol phosphate multikinase | - |
Homo sapiens |
InsP4 5-kinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | enzyme contains the putative binding site P-X-X-X-D-X-K-X-G | Homo sapiens |