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Literature summary for 2.7.1.151 extracted from
- Inositol polyphosphate multikinase: metabolic architect of nuclear inositides (2008), Front. Biosci., 13, 856-866.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | putative treatment of cancer | Drosophila melanogaster |
| medicine | putative treatment of cancer | Homo sapiens |
| medicine | putative treatment of cancer | Rattus norvegicus |
| medicine | putative treatment of cancer | Saccharomyces cerevisiae |
| medicine | putative treatment of cancer | Solanum tuberosum |
| medicine | putative treatment of cancer | Arabidopsis thaliana |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Examinations of plants deficient in IPMK suggest roles in pollen germination, root growth, as well axillary shoot branching. | Solanum tuberosum |
| IPMK knockout mice demonstrates the critical roles of IPMK in embryogenesis and central nevous system development. Deletion of IPMK in mice results in early lethality. | Homo sapiens |
| IPMK knockout mice demonstrates the critical roles of IPMK in embryogenesis and central nevous system development. Deletion of IPMK in mice results in early lethality. | Rattus norvegicus |
| Observed derepression and constitutive elevated levels levels of the transcripts in IPMK mutant yeast but not in ipk1- or ipk6-deficient yeasts confirms the requirement of IPMK in the transcriptional regulation of arginine anabolism and catabolism. | Saccharomyces cerevisiae |
| While wild-type yeast displays sequential phosphorylation of Ins(1,4,5)P3 to Ins6, mutation of locus termed GSL3 resulted in the loss of Ins(1,4,5)P3-initiated higher isnositol polyphosphate metabolism. IPMK is identified as GSL3 (Ipk2) and confirmed its requirement for mRNA export. | Saccharomyces cerevisiae |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| Structure database comparisons of the recently solved crystal strucures of Ins(1,4,5)P3-kinase and IPMK confirm the close structural relationship to the lipid inositol kinases despite little primary amino acid sequence similarities. | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | IPMK3s phosphoinositide-3 kinase activity is distinguished from previously described phosphoinositide-3 kinase in its complete insensitivity to pharmacological inhibition by wortmannin, a potent inhibitor of canonical phosphoinositide-3 kinase.; selective hypersensitivity to rapamycin, an inhibitor of the TOP (target of rapamycin) kinases wit preeminent regulatory roles in general nitrogencatabolite repression control. | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Drosophila melanogaster | 5634 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
| nucleus | - |
Rattus norvegicus | 5634 | - |
| nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
| nucleus | - |
Solanum tuberosum | 5634 | - |
| nucleus | - |
Arabidopsis thaliana | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | Drosophila melanogaster | - |
2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? |  |
| 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | Arabidopsis thaliana | - |
2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | Homo sapiens | in rats and humans | 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | Rattus norvegicus | in rats and humans | 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | - |
2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
r | |
| 2 ATP + 1D-myo-inositol 4,5-bisphosphate | Rattus norvegicus | - |
2 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
| 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate | Drosophila melanogaster | - |
3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate | Arabidopsis thaliana | - |
3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | in rats and humans | 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | in rats and humans | 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| ATP + 1D-myo-inositol 1,2,3,4,6-pentakisphosphate | Arabidopsis thaliana | - |
ADP + inositol hexakisphosphate | - |
? | |
| ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | Arabidopsis thaliana | - |
ADP + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
r | |
| ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| ATP + 1D-myo-inositol 1,4,5-trisphosphate | Saccharomyces cerevisiae | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
r | |
| ATP + phosphatidylinositol 4,5-bisphosphate | Rattus norvegicus | in rats | ADP + phosphatidylinositol 3,4,5-trisphosphate | - |
? | |
| ATP + phosphatidylinositol 4,5-bisphosphate | Solanum tuberosum | - |
ADP + phosphatidylinositol (3,4,5)-trisphosphate | - |
? | |
| additional information | Drosophila melanogaster | Genome-wide RNA interference screen in cultured Drosophila melanogaster haemocyte-like cells identifies as a regulator of the Janus tyrosine kinase/signal transducer and activator of transcription. | ? | - |
? | |
| additional information | Homo sapiens | role in chromatin remodelling | ? | - |
? | |
| additional information | Rattus norvegicus | role in chromatin remodelling | ? | - |
? | |
| additional information | Homo sapiens | Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of inositol pentakisphosphate and inositol hexakisphosphate | ? | - |
? | |
| additional information | Rattus norvegicus | Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of InsP5 and InsP6 | ? | - |
? | |
| additional information | Homo sapiens | The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells. | ? | - |
? | |
| additional information | Rattus norvegicus | The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells. | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order. | - |
| Drosophila melanogaster | - |
Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order. | - |
| Homo sapiens | - |
Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order. | - |
| Rattus norvegicus | - |
Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order. | - |
| Saccharomyces cerevisiae | - |
Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order. | - |
| Solanum tuberosum | - |
Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order. | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Drosophila melanogaster |
| phosphoprotein | - |
Homo sapiens |
| phosphoprotein | - |
Rattus norvegicus |
| phosphoprotein | - |
Saccharomyces cerevisiae |
| phosphoprotein | - |
Solanum tuberosum |
| phosphoprotein | - |
Arabidopsis thaliana |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
water-soluble kinase activity and phosphoinositide kinase activity | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | - |
Drosophila melanogaster | 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | - |
Arabidopsis thaliana | 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | in rats and humans | Homo sapiens | 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | in rats and humans | Rattus norvegicus | 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
r | |
| 2 ATP + 1D-myo-inositol 4,5-bisphosphate | - |
Rattus norvegicus | 2 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
| 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate | - |
Drosophila melanogaster | 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate | - |
Arabidopsis thaliana | 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate | in rats and humans | Homo sapiens | 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate | in rats and humans | Rattus norvegicus | 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| ATP + 1D-myo-inositol 1,2,3,4,6-pentakisphosphate | - |
Arabidopsis thaliana | ADP + inositol hexakisphosphate | - |
? | |
| ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | - |
Arabidopsis thaliana | ADP + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
r | |
| ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
| ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Saccharomyces cerevisiae | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
r | |
| ATP + phosphatidylinositol 4,5-bisphosphate | in rats | Rattus norvegicus | ADP + phosphatidylinositol 3,4,5-trisphosphate | - |
? | |
| ATP + phosphatidylinositol 4,5-bisphosphate | - |
Solanum tuberosum | ADP + phosphatidylinositol (3,4,5)-trisphosphate | - |
? | |
| additional information | Genome-wide RNA interference screen in cultured Drosophila melanogaster haemocyte-like cells identifies as a regulator of the Janus tyrosine kinase/signal transducer and activator of transcription. | Drosophila melanogaster | ? | - |
? | |
| additional information | role in chromatin remodelling | Homo sapiens | ? | - |
? | |
| additional information | role in chromatin remodelling | Rattus norvegicus | ? | - |
? | |
| additional information | Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of inositol pentakisphosphate and inositol hexakisphosphate | Homo sapiens | ? | - |
? | |
| additional information | Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of InsP5 and InsP6 | Rattus norvegicus | ? | - |
? | |
| additional information | The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells. | Homo sapiens | ? | - |
? | |
| additional information | The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells. | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Arg82 | enzyme is an arginine-sensitive nuclear transcription factor | Saccharomyces cerevisiae |
| ARGSIII | - |
Saccharomyces cerevisiae |
| AtIpk2a | - |
Arabidopsis thaliana |
| AtIpk2b | - |
Arabidopsis thaliana |
| Ins(1,4,5)P3 3-kinase | - |
Homo sapiens |
| Ins(1,4,5)P3 3-kinase | - |
Rattus norvegicus |
| InsP4 5-kinase | in humans | Homo sapiens |
| Ipk2 | - |
Drosophila melanogaster |
| Ipk2 | - |
Saccharomyces cerevisiae |
| IPKII | - |
Saccharomyces cerevisiae |
| IPMK | - |
Saccharomyces cerevisiae |
| IPMK | enzyme phosphorylates sequentially inositol trisphosphate to inositol heakisphosphate | Solanum tuberosum |
| IPMK | enzyme phosphorylates sequentially inositol trisphosphate to inositol hexakisphosphate | Homo sapiens |
| IPMK | enzyme phosphorylates sequentially InsP3 to InsP6 | Rattus norvegicus |
| PI3K | non-canonical | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Drosophila melanogaster | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
| ATP | - |
Saccharomyces cerevisiae | |
| ATP | - |
Solanum tuberosum | |
| ATP | - |
Arabidopsis thaliana | |
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