Crystallization (Comment) | Organism |
---|---|
isoform inositol phosphate multikinase alpha, to 2.9 A resolution. The structural core of Arabidopsis thaliana IPMK is homologous to those of Saccharamyces cerevisiae IPMK and Homo sapiens IP3K | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
K117W | mutant exhibits nearly normal 6-kinase function but harbors significantly reduced 3-kinase activity. The mutant complements conditional nutritional growth defects observed in ipmk null yeast and suppresses lethality observed in ipmk null flies | Arabidopsis thaliana |
K117W/K121W | mutant exhibits nearly normal 6-kinase function but harbors significantly reduced 3-kinase activity. The mutant complements conditional nutritional growth defects observed in ipmk null yeast and suppresses lethality observed in ipmk null flies | Arabidopsis thaliana |
K121W | although no inositol tetrakisphosphate is present with wild-type IPMK, levels of inositol tetrakisphosphate and inositol hexakisphosphate are equivalent in mutant K121W | Arabidopsis thaliana |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0308 | - |
1D-myo-inositol 1,3,4,5-tetrakisphosphate | wild-type, pH 6.6, 30°C | Arabidopsis thaliana | |
0.05 | - |
1D-myo-inositol 1,4,5-trisphosphate | mutant K121W, pH 6.6, 30°C | Arabidopsis thaliana | |
0.075 | - |
1D-myo-inositol 1,4,5,6-tetrakisphosphate | wild-type, pH 6.6, 30°C | Arabidopsis thaliana | |
0.162 | - |
1D-myo-inositol 1,4,5-trisphosphate | wild-type, pH 6.6, 30°C | Arabidopsis thaliana | |
0.216 | - |
1D-myo-inositol 1,4,5,6-tetrakisphosphate | mutant K121W, pH 6.6, 30°C | Arabidopsis thaliana | |
0.254 | - |
1D-myo-inositol 1,4,5,6-tetrakisphosphate | mutant K117W, pH 6.6, 30°C | Arabidopsis thaliana | |
0.49 | - |
1D-myo-inositol 1,3,4,5-tetrakisphosphate | mutant K121W, pH 6.6, 30°C | Arabidopsis thaliana | |
0.568 | - |
1D-myo-inositol 1,3,4,5-tetrakisphosphate | mutant K117W, pH 6.6, 30°C | Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q9LY23 | isoform inositol phosphate multikinase alpha | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
Arabidopsis thaliana | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | - |
Arabidopsis thaliana | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Arabidopsis thaliana | ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Arg82 | - |
Arabidopsis thaliana |
Ipk2a | - |
Arabidopsis thaliana |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.97 | - |
1D-myo-inositol 1,4,5,6-tetrakisphosphate | mutant K121W, pH 6.6, 30°C | Arabidopsis thaliana | |
2.04 | - |
1D-myo-inositol 1,4,5,6-tetrakisphosphate | mutant K117W, pH 6.6, 30°C | Arabidopsis thaliana | |
5.8 | - |
1D-myo-inositol 1,3,4,5-tetrakisphosphate | mutant K117W, pH 6.6, 30°C | Arabidopsis thaliana | |
7.3 | - |
1D-myo-inositol 1,3,4,5-tetrakisphosphate | mutant K121W, pH 6.6, 30°C | Arabidopsis thaliana | |
29.7 | - |
1D-myo-inositol 1,4,5-trisphosphate | pH 6.6, 30°C | Arabidopsis thaliana | |
37.8 | - |
1D-myo-inositol 1,4,5-trisphosphate | mutant K121W, pH 6.6, 30°C | Arabidopsis thaliana | |
79.1 | - |
1D-myo-inositol 1,4,5,6-tetrakisphosphate | pH 6.6, 30°C | Arabidopsis thaliana | |
106 | - |
1D-myo-inositol 1,3,4,5-tetrakisphosphate | pH 6.6, 30°C | Arabidopsis thaliana |