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Literature summary for 2.7.1.151 extracted from

  • Endo-Streeter, S.; Tsui, M.K.; Odom, A.R.; Block, J.; York, J.D.
    Structural studies and protein engineering of inositol phosphate multikinase (2012), J. Biol. Chem., 287, 35360-35369.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
isoform inositol phosphate multikinase alpha, to 2.9 A resolution. The structural core of Arabidopsis thaliana IPMK is homologous to those of Saccharamyces cerevisiae IPMK and Homo sapiens IP3K Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
K117W mutant exhibits nearly normal 6-kinase function but harbors significantly reduced 3-kinase activity. The mutant complements conditional nutritional growth defects observed in ipmk null yeast and suppresses lethality observed in ipmk null flies Arabidopsis thaliana
K117W/K121W mutant exhibits nearly normal 6-kinase function but harbors significantly reduced 3-kinase activity. The mutant complements conditional nutritional growth defects observed in ipmk null yeast and suppresses lethality observed in ipmk null flies Arabidopsis thaliana
K121W although no inositol tetrakisphosphate is present with wild-type IPMK, levels of inositol tetrakisphosphate and inositol hexakisphosphate are equivalent in mutant K121W Arabidopsis thaliana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0308
-
1D-myo-inositol 1,3,4,5-tetrakisphosphate wild-type, pH 6.6, 30°C Arabidopsis thaliana
0.05
-
1D-myo-inositol 1,4,5-trisphosphate mutant K121W, pH 6.6, 30°C Arabidopsis thaliana
0.075
-
1D-myo-inositol 1,4,5,6-tetrakisphosphate wild-type, pH 6.6, 30°C Arabidopsis thaliana
0.162
-
1D-myo-inositol 1,4,5-trisphosphate wild-type, pH 6.6, 30°C Arabidopsis thaliana
0.216
-
1D-myo-inositol 1,4,5,6-tetrakisphosphate mutant K121W, pH 6.6, 30°C Arabidopsis thaliana
0.254
-
1D-myo-inositol 1,4,5,6-tetrakisphosphate mutant K117W, pH 6.6, 30°C Arabidopsis thaliana
0.49
-
1D-myo-inositol 1,3,4,5-tetrakisphosphate mutant K121W, pH 6.6, 30°C Arabidopsis thaliana
0.568
-
1D-myo-inositol 1,3,4,5-tetrakisphosphate mutant K117W, pH 6.6, 30°C Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9LY23 isoform inositol phosphate multikinase alpha
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
Arabidopsis thaliana ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
Arabidopsis thaliana ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Arabidopsis thaliana ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
?

Synonyms

Synonyms Comment Organism
Arg82
-
Arabidopsis thaliana
Ipk2a
-
Arabidopsis thaliana

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.97
-
1D-myo-inositol 1,4,5,6-tetrakisphosphate mutant K121W, pH 6.6, 30°C Arabidopsis thaliana
2.04
-
1D-myo-inositol 1,4,5,6-tetrakisphosphate mutant K117W, pH 6.6, 30°C Arabidopsis thaliana
5.8
-
1D-myo-inositol 1,3,4,5-tetrakisphosphate mutant K117W, pH 6.6, 30°C Arabidopsis thaliana
7.3
-
1D-myo-inositol 1,3,4,5-tetrakisphosphate mutant K121W, pH 6.6, 30°C Arabidopsis thaliana
29.7
-
1D-myo-inositol 1,4,5-trisphosphate pH 6.6, 30°C Arabidopsis thaliana
37.8
-
1D-myo-inositol 1,4,5-trisphosphate mutant K121W, pH 6.6, 30°C Arabidopsis thaliana
79.1
-
1D-myo-inositol 1,4,5,6-tetrakisphosphate pH 6.6, 30°C Arabidopsis thaliana
106
-
1D-myo-inositol 1,3,4,5-tetrakisphosphate pH 6.6, 30°C Arabidopsis thaliana