Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | glucose activates phosphorylation of IPMK at residue Tyr174 enabling the enzyme to bind to AMP-activated kinase and regulate its activation | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypothalamus | - |
Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
More | IPMK physiologically binds AMP-activated kinase, with binding enhanced by glucose treatment | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | inositol polyphosphate multikinase IPMK regulates glucose signaling to AMP-activated kinase in a pathway whereby glucose activates phosphorylation of IPMK at residue Tyr174 enabling the enzyme to bind to AMP-activated kinase and regulate its activation. Refeeding fasted mice rapidly and markedly stimulates transcriptional enhancement of IPMK expression while down-regulating AMP-activated kinase. AMP-activated kinase is up-regulated in mice with genetic depletion of hypothalamic IPMK. IPMK physiologically binds AMP-activated kinase, with binding enhanced by glucose treatment. Regulation by glucose of phospho-AMP-activated kinase in hypothalamic cell lines is prevented by blocking AMP-activated kinase-IPMK binding | Mus musculus |