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Literature summary for 2.7.1.153 extracted from

  • Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Driscoll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.
    Synthesis and function of 3-phosphorylated inositol lipids (2001), Annu. Rev. Biochem., 70, 535-602.
    View publication on PubMed
Search for more literature for 2.7.1.153

Activating Compound

Activating Compound Comment Organism Structure
additional information stimulation of almost every receptor that induces tyrosine kinase activity also leads to class IA phosphatidylinositol-4,5-bisphosphate 3-kinase activation Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
expression of P110delta in Sf9 insect cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Mammalia

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Homo sapiens
LY294002
-
 Mammalia
Wortmannin
-
 Homo sapiens
Wortmannin
-
 Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mammalia 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens
-
 ?
-
 ?
additional information Drosophila melanogaster enzyme can promote proliferation ?
-
 ?
additional information Mammalia enzyme can promote proliferation ?
-
 ?
additional information Drosophila melanogaster phosphoinositide 3-kinase and DNA synthesis ?
-
 ?
additional information Mammalia phosphoinositide 3-kinase and DNA synthesis ?
-
 ?
additional information Dictyostelium discoideum phosphoinositide 3-kinase and DNA synthesis ?
-
 ?
additional information Caenorhabditis elegans phosphoinositide 3-kinase and DNA synthesis ?
-
 ?
additional information Drosophila melanogaster enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear ?
-
 ?
additional information Mammalia enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear ?
-
 ?
additional information Dictyostelium discoideum enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear ?
-
 ?
additional information Caenorhabditis elegans enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear ?
-
 ?
additional information Drosophila melanogaster phosphoinositide 3-kinase and apoptosis ?
-
 ?
additional information Mammalia phosphoinositide 3-kinase and apoptosis ?
-
 ?
additional information Dictyostelium discoideum phosphoinositide 3-kinase and apoptosis ?
-
 ?
additional information Caenorhabditis elegans phosphoinositide 3-kinase and apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Dictyostelium discoideum
-
-
-
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Mammalia
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Mammalia
-
leukocyte
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MOLT-4 cell
-
 Homo sapiens
-
additional information all mammalian cell types investigated express at least one class IA isoform, class IB isoform is present only in mammals, where it shows a restricted tissue distribution, being abundant only in white blood cells Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Drosophila melanogaster ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Mammalia ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Dictyostelium discoideum ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Caenorhabditis elegans ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + phosphatidylinositol
-
 Drosophila melanogaster ADP + phosphatidylinositol 3-phosphate
-
 ?
ATP + phosphatidylinositol
-
 Mammalia ADP + phosphatidylinositol 3-phosphate
-
 ?
ATP + phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?
ATP + phosphatidylinositol
-
 Dictyostelium discoideum ADP + phosphatidylinositol 3-phosphate
-
 ?
ATP + phosphatidylinositol
-
 Caenorhabditis elegans ADP + phosphatidylinositol 3-phosphate
-
 ?
ATP + phosphatidylinositol 4-phosphate
-
 Drosophila melanogaster ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
ATP + phosphatidylinositol 4-phosphate
-
 Mammalia ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
ATP + phosphatidylinositol 4-phosphate
-
 Homo sapiens ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
ATP + phosphatidylinositol 4-phosphate
-
 Dictyostelium discoideum ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
ATP + phosphatidylinositol 4-phosphate
-
 Caenorhabditis elegans ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
additional information
-
 Homo sapiens ?
-
 ?
additional information enzyme can promote proliferation Drosophila melanogaster ?
-
 ?
additional information enzyme can promote proliferation Mammalia ?
-
 ?
additional information phosphoinositide 3-kinase and DNA synthesis Drosophila melanogaster ?
-
 ?
additional information phosphoinositide 3-kinase and DNA synthesis Mammalia ?
-
 ?
additional information phosphoinositide 3-kinase and DNA synthesis Dictyostelium discoideum ?
-
 ?
additional information phosphoinositide 3-kinase and DNA synthesis Caenorhabditis elegans ?
-
 ?
additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Drosophila melanogaster ?
-
 ?
additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Mammalia ?
-
 ?
additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Dictyostelium discoideum ?
-
 ?
additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Caenorhabditis elegans ?
-
 ?
additional information phosphoinositide 3-kinase and apoptosis Drosophila melanogaster ?
-
 ?
additional information phosphoinositide 3-kinase and apoptosis Mammalia ?
-
 ?
additional information phosphoinositide 3-kinase and apoptosis Dictyostelium discoideum ?
-
 ?
additional information phosphoinositide 3-kinase and apoptosis Caenorhabditis elegans ?
-
 ?

Subunits

Subunits Comment Organism
More class I phosphoinositide 3-kinases are heterodimers made up of an catalytic subunit, called p110, of about 110000 Da and an adaptor/regulatory subunit. Class I phosphoinositide 3-kinases are further subdivided into class Ia and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively Drosophila melanogaster
More class I phosphoinositide 3-kinases are heterodimers made up of an catalytic subunit, called p110, of about 110000 Da and an adaptor/regulatory subunit. Class I phosphoinositide 3-kinases are further subdivided into class Ia and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively Mammalia
More class I phosphoinositide 3-kinases are heterodimers made up of an catalytic subunit, called p110, of about 110000 Da and an adaptor/regulatory subunit. Class I phosphoinositide 3-kinases are further subdivided into class Ia and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively Dictyostelium discoideum
More class I phosphoinositide 3-kinases are heterodimers made up of an catalytic subunit, called p110, of about 110000 Da and an adaptor/regulatory subunit. Class I phosphoinositide 3-kinases are further subdivided into class Ia and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively Caenorhabditis elegans
More a single type of catalytic/adaptor heterodimer: AGE-1/AAP-1 Caenorhabditis elegans
More a single type of catalytic/adaptor heterodimer: Dp110/p60 Drosophila melanogaster
More three class IA p110 isoforms, p110alpha, beta and delta, which are encoded by three separate genes, at least seven adaptor proteins, which are generated by expression and alternative splicing of three different genes, namely p85alpha, p85beta and p55gamma. All these splice variants make functional complexes with p110 subunits Mammalia
More three catalytic subunits: PIK1, PIK2 or PIK3 Dictyostelium discoideum