Cloned (Comment) | Organism |
---|---|
gene PIK3CA, encodes the catalytic subunit of PI3K, and resides in chromosomal area 3q26 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | specific inhibitor | Homo sapiens | |
additional information | inhibition of PIK3CA induces apoptosis in mantle cell lymphoma cell lines | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene PIK3CA enocding the PI3K catalytic subunit alpha | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mantle cell lymphoma cell | 68% of clinical cases and the MCL cell lines harbor a gain of PIK3 catalytic subunit alpha gene copy number. In addition, cases with increased PIK3CA gene copy number have elevated PIK3CA mRNA levels | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 3'-kinase | - |
Homo sapiens |
PI3K | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | gain of copy number of PIK3CA gene by gene amplification in mantle cell lymphoma is one mechanism of oncogenic activation of PI3K. Expression of PIK3CA in mantle cell lymphoma correlates with gene copy numbers determined by real-time PCR, overview | additional information |
General Information | Comment | Organism |
---|---|---|
malfunction | deregulated signaling through phosphatidylinositol 3'-kinase pathway is common in many types of malignancies, including mantle cell lymphoma. PI3K catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma. Inhibition of PIK3CA induces apoptosis in mantle cell lymphoma cell lines | Homo sapiens |