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Literature summary for 2.7.1.153 extracted from

  • Psyrri, A.; Papageorgiou, S.; Liakata, E.; Scorilas, A.; Rontogianni, D.; Kontos, C.K.; Argyriou, P.; Pectasides, D.; Harhalakis, N.; Pappa, V.; Kolialexi, A.; Economopoulou, C.; Kontsioti, F.; Maratou, E.; Dimitriadis, G.; Economopoulou, P.; Economopoulos, T.
    Phosphatidylinositol 3-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma (2009), Clin. Cancer Res., 15, 5724-5732.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene PIK3CA, encodes the catalytic subunit of PI3K, and resides in chromosomal area 3q26 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002 specific inhibitor Homo sapiens
additional information inhibition of PIK3CA induces apoptosis in mantle cell lymphoma cell lines Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
gene PIK3CA enocding the PI3K catalytic subunit alpha
-

Source Tissue

Source Tissue Comment Organism Textmining
mantle cell lymphoma cell 68% of clinical cases and the MCL cell lines harbor a gain of PIK3 catalytic subunit alpha gene copy number. In addition, cases with increased PIK3CA gene copy number have elevated PIK3CA mRNA levels Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 3'-kinase
-
Homo sapiens
PI3K
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens gain of copy number of PIK3CA gene by gene amplification in mantle cell lymphoma is one mechanism of oncogenic activation of PI3K. Expression of PIK3CA in mantle cell lymphoma correlates with gene copy numbers determined by real-time PCR, overview additional information

General Information

General Information Comment Organism
malfunction deregulated signaling through phosphatidylinositol 3'-kinase pathway is common in many types of malignancies, including mantle cell lymphoma. PI3K catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma. Inhibition of PIK3CA induces apoptosis in mantle cell lymphoma cell lines Homo sapiens