Activating Compound | Comment | Organism | Structure |
---|---|---|---|
TNF-alpha | activates PI3K | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | a specific #PI3K inhibitor | Mus musculus | |
quercetin | from red wine extract, quercetin and red wine polyphenol extract inhibit the phosphorylation of Akt in vivo and show inhibitory effects on TNF-alpha-induced upregulation of MMP-9 and on the migratory phenotype of JB6 P+ mouse epidermal, mediated by suppression of the phosphorylation of Akt and the transactivation of activator protein-1 and nuclear factor-kappaB. Red wine extract and quercetin suppress TNF-alpha-induced PI3K activity by binding specifically to PI3K | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Mus musculus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | Mus musculus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate | phosphatidylinositol-3,4,5-triphosphate is a major product of active PI3K, and recruits Akt/PKB to the plasma membrane and the phosphorylation of Akt occurs | ? | |
ATP + Akt | Mus musculus | - |
ADP + Akt phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JB6 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate | phosphatidylinositol-3,4,5-triphosphate is a major product of active PI3K, and recruits Akt/PKB to the plasma membrane and the phosphorylation of Akt occurs | ? | |
ATP + Akt | - |
Mus musculus | ADP + Akt phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9 | Mus musculus |