Cloned (Comment) | Organism |
---|---|
expression in COS-7 cells | Mus musculus |
expression in COS-7 cells. Specific activity of the enzyme purified from Drosophila lysate is significantly higher than that of Cpk derived from exogenous expression in COS-7 cells | Drosophila melanogaster |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Wortmannin | IC50: 11 nM | Drosophila melanogaster |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | the enzyme strictly requires the presence of Mg2+, inactive in presence of Mn2+ | Drosophila melanogaster | |
additional information | inactive in presence of Mn2+ | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q7JNX6 | - |
- |
Mus musculus | Q61194 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate | - |
Drosophila melanogaster | ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | - |
? | |
ATP + phosphatidylinositol | - |
Drosophila melanogaster | ADP + phosphatidylinositol 3-phosphate | - |
? | |
additional information | no activity with phosphatidylinositol 4,5-diphosphate | Drosophila melanogaster | ? | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000011 | - |
IC50: 11 nM | Drosophila melanogaster | Wortmannin |