Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F444A | mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme | Homo sapiens |
F444C | mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme but increases turnover rate with N-acetylgalactosamine | Homo sapiens |
F444H | mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme | Homo sapiens |
F444K | mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme | Homo sapiens |
F444R | mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme | Homo sapiens |
F444S | mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme but increases turnover rate with N-acetylgalactosamine | Homo sapiens |
F444W | mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.006 | - |
ATP | mutant F444A, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine | Homo sapiens | |
0.009 | - |
ATP | mutant F444R, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine | Homo sapiens | |
0.009 | - |
ATP | wild-type, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine | Homo sapiens | |
0.011 | - |
ATP | mutant F444H, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine | Homo sapiens | |
0.013 | - |
ATP | mutant F444H, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine | Homo sapiens | |
0.013 | - |
ATP | mutant F444S, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine | Homo sapiens | |
0.015 | - |
ATP | mutant F444K, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine | Homo sapiens | |
0.015 | - |
ATP | mutant F444K, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine | Homo sapiens | |
0.015 | - |
ATP | mutant F444R, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine | Homo sapiens | |
0.017 | - |
ATP | mutant F444C, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine | Homo sapiens | |
0.017 | - |
ATP | mutant F444H, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine | Homo sapiens | |
0.018 | - |
ATP | mutant F444C, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine | Homo sapiens | |
0.018 | - |
ATP | wild-type, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine | Homo sapiens | |
0.019 | - |
ATP | mutant F444S, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine | Homo sapiens | |
0.024 | - |
ATP | mutant F444R, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine | Homo sapiens | |
0.024 | - |
ATP | mutant F444W, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine | Homo sapiens | |
0.025 | - |
ATP | mutant F444A, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine | Homo sapiens | |
0.027 | - |
ATP | mutant F444C, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine | Homo sapiens | |
0.028 | - |
ATP | mutant F444K, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine | Homo sapiens | |
0.032 | - |
ATP | wild-type, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine | Homo sapiens | |
0.039 | - |
ATP | mutant F444A, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine | Homo sapiens | |
0.051 | - |
N-acetyl-alpha-D-glucosamine | wild-type, 37°C, pH 7.5 | Homo sapiens | |
0.12 | - |
N-acetyl-alpha-D-glucosamine | mutant F444K, 37°C, pH 7.5 | Homo sapiens | |
0.12 | - |
N-acetyl-alpha-D-glucosamine | mutant F444S, 37°C, pH 7.5 | Homo sapiens | |
0.13 | - |
ATP | mutant F444S, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine | Homo sapiens | |
0.17 | - |
N-acetyl-alpha-D-galactosamine | mutant F444R, 37°C, pH 7.5 | Homo sapiens | |
0.22 | - |
N-acetyl-alpha-D-glucosamine | mutant F444H, 37°C, pH 7.5 | Homo sapiens | |
0.24 | - |
N-acetyl-alpha-D-galactosamine | mutant F444A, 37°C, pH 7.5 | Homo sapiens | |
0.25 | - |
N-acetyl-alpha-D-mannosamine | mutant F444H, 37°C, pH 7.5 | Homo sapiens | |
0.27 | - |
N-acetyl-alpha-D-galactosamine | mutant F444H, 37°C, pH 7.5 | Homo sapiens | |
0.28 | - |
N-acetyl-alpha-D-glucosamine | mutant F444R, 37°C, pH 7.5 | Homo sapiens | |
0.33 | - |
N-acetyl-alpha-D-galactosamine | wild-type, 37°C, pH 7.5 | Homo sapiens | |
0.34 | - |
N-acetyl-alpha-D-galactosamine | mutant F444K, 37°C, pH 7.5 | Homo sapiens | |
0.37 | - |
N-acetyl-alpha-D-glucosamine | mutant F444A, 37°C, pH 7.5 | Homo sapiens | |
0.39 | - |
N-acetyl-alpha-D-glucosamine | mutant F444C, 37°C, pH 7.5 | Homo sapiens | |
0.47 | - |
N-acetyl-alpha-D-mannosamine | mutant F444C, 37°C, pH 7.5 | Homo sapiens | |
0.56 | - |
N-acetyl-alpha-D-galactosamine | mutant F444S, 37°C, pH 7.5 | Homo sapiens | |
0.65 | - |
N-acetyl-alpha-D-mannosamine | mutant F444R, 37°C, pH 7.5 | Homo sapiens | |
0.69 | - |
N-acetyl-alpha-D-galactosamine | mutant F444W, 37°C, pH 7.5 | Homo sapiens | |
0.79 | - |
N-acetyl-alpha-D-mannosamine | wild-type, 37°C, pH 7.5 | Homo sapiens | |
0.93 | - |
N-acetyl-alpha-D-mannosamine | mutant F444A, 37°C, pH 7.5 | Homo sapiens | |
0.95 | - |
N-acetyl-alpha-D-galactosamine | mutant F444C, 37°C, pH 7.5 | Homo sapiens | |
0.95 | - |
N-acetyl-alpha-D-mannosamine | mutant F444K, 37°C, pH 7.5 | Homo sapiens | |
4.1 | - |
N-acetyl-alpha-D-mannosamine | mutant F444S, 37°C, pH 7.5 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q01415 | isoform GALK2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + N-acetyl-alpha-D-galactosamine | - |
Homo sapiens | ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
? | |
ATP + N-acetyl-alpha-D-glucosamine | - |
Homo sapiens | ADP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
? | |
ATP + N-acetyl-alpha-D-mannosamine | - |
Homo sapiens | ADP + N-acetyl-alpha-D-mannosamine 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GALK2 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.053 | - |
N-acetyl-alpha-D-mannosamine | mutant F444H, 37°C, pH 7.5 | Homo sapiens | |
0.063 | - |
N-acetyl-alpha-D-glucosamine | mutant F444S, 37°C, pH 7.5 | Homo sapiens | |
0.066 | - |
N-acetyl-alpha-D-mannosamine | mutant F444C, 37°C, pH 7.5 | Homo sapiens | |
0.071 | - |
N-acetyl-alpha-D-glucosamine | mutant F444R, 37°C, pH 7.5 | Homo sapiens | |
0.072 | - |
N-acetyl-alpha-D-glucosamine | mutant F444H, 37°C, pH 7.5 | Homo sapiens | |
0.087 | - |
N-acetyl-alpha-D-glucosamine | mutant F444C, 37°C, pH 7.5 | Homo sapiens | |
0.11 | - |
N-acetyl-alpha-D-glucosamine | mutant F444A, 37°C, pH 7.5 | Homo sapiens | |
0.16 | - |
N-acetyl-alpha-D-glucosamine | wild-type, 37°C, pH 7.5 | Homo sapiens | |
0.18 | - |
N-acetyl-alpha-D-glucosamine | mutant F444K, 37°C, pH 7.5 | Homo sapiens | |
0.19 | - |
N-acetyl-alpha-D-mannosamine | mutant F444R, 37°C, pH 7.5 | Homo sapiens | |
0.19 | - |
N-acetyl-alpha-D-mannosamine | wild-type, 37°C, pH 7.5 | Homo sapiens | |
0.23 | - |
N-acetyl-alpha-D-mannosamine | mutant F444A, 37°C, pH 7.5 | Homo sapiens | |
0.25 | - |
N-acetyl-alpha-D-mannosamine | mutant F444K, 37°C, pH 7.5 | Homo sapiens | |
0.4 | - |
N-acetyl-alpha-D-mannosamine | mutant F444S, 37°C, pH 7.5 | Homo sapiens | |
0.62 | - |
N-acetyl-alpha-D-galactosamine | mutant F444W, 37°C, pH 7.5 | Homo sapiens | |
0.72 | - |
N-acetyl-alpha-D-galactosamine | mutant F444R, 37°C, pH 7.5 | Homo sapiens | |
1 | - |
N-acetyl-alpha-D-galactosamine | mutant F444K, 37°C, pH 7.5 | Homo sapiens | |
1.2 | - |
N-acetyl-alpha-D-galactosamine | wild-type, 37°C, pH 7.5 | Homo sapiens | |
1.6 | - |
N-acetyl-alpha-D-galactosamine | mutant F444H, 37°C, pH 7.5 | Homo sapiens | |
1.9 | - |
N-acetyl-alpha-D-galactosamine | mutant F444A, 37°C, pH 7.5 | Homo sapiens | |
2.6 | - |
N-acetyl-alpha-D-galactosamine | mutant F444C, 37°C, pH 7.5 | Homo sapiens | |
3.2 | - |
N-acetyl-alpha-D-galactosamine | mutant F444S, 37°C, pH 7.5 | Homo sapiens |