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Literature summary for 2.7.1.171 extracted from

  • Delpierre, G.; Rider, M.H.; Collard, F.; Stroobant, V.; Vanstapel, F.; Santos, H.; van Schaftingen, E.
    Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase (2000), Diabetes, 49, 1627-1634.
    View publication on PubMed
Search for more literature for 2.7.1.171

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 1-deoxy-1-morpholin-4-yl-D-fructose pH 7.8, 30°C Mus musculus
0.001
-
 N2-(1-deoxy-D-fructosyl)-glycine pH 7.8, 30°C Mus musculus
0.001
-
 1-deoxy-1-morpholin-4-yl-D-fructose pH 7.8, 30°C, erythrocyte enzyme Homo sapiens
0.001
-
 N2-(1-deoxy-D-fructosyl)-glycine pH 7.8, 30°C, erythrocyte enzyme Homo sapiens
0.001
-
 1-deoxy-1-morpholin-4-yl-D-fructose pH 7.8, 30°C, recombinant enzyme Homo sapiens
0.0022
-
 N2-(1-deoxy-D-fructosyl)-glycine pH 7.8, 30°C, recombinant enzyme Homo sapiens
0.0072
-
 N6-(1-deoxy-D-fructosyl)-L-lysine
-
 Homo sapiens
0.0072
-
 N6-(1-deoxy-D-fructosyl)-lysine pH 7.8, 30°C, recombinant enzyme Homo sapiens
0.0074
-
 N6-(1-deoxy-D-fructosyl)-lysine pH 7.8, 30°C Mus musculus
0.0132
-
 N6-(1-deoxy-D-fructosyl)-lysine pH 7.8, 30°C, erythrocyte enzyme Homo sapiens
0.8
-
 N2-(1-deoxy-D-fructosyl)-L-valine
-
 Homo sapiens
1.5
-
 N2-(1-deoxy-D-fructosyl)-glycylglycine
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 x * 35000, SDS-PAGE Mus musculus
35000
-
 x * 35000, SDS-PAGE Homo sapiens
35032
-
 x * 35032, calculated from sequence Mus musculus
35032
-
 x * 35032, calculated from sequence Homo sapiens
35171
-
 x * 35171, calculated from sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-N6-D-fructosyl-L-lysine Mus musculus the physiological function of fructosamine-3-kinase may be to initiate a process leading to the deglycation of fructoselysine and of glycated proteins ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
 ?
ATP + [protein]-N6-D-fructosyl-L-lysine Homo sapiens the physiological function of fructosamine-3-kinase may be to initiate a process leading to the deglycation of fructoselysine and of glycated proteins ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H479
-
-
Mus musculus Q9ER35
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Mus musculus
-
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-deoxy-1-morpholin-4-yl-D-fructose
-
 Mus musculus ADP + 1-deoxy-1-morpholin-4-yl-3-O-phosphono-D-fructose
-
 ?
ATP + 1-deoxy-1-morpholin-4-yl-D-fructose
-
 Homo sapiens ADP + 1-deoxy-1-morpholin-4-yl-3-O-phosphono-D-fructose
-
 ?
ATP + D-fructose
-
 Mus musculus ADP + O3-phosphono-D-fructose
-
 ?
ATP + D-fructose
-
 Homo sapiens ADP + O3-phosphono-D-fructose
-
 ?
ATP + N2-(1-deoxy-D-fructosyl)-glycine
-
 Mus musculus ADP + N2-(1-deoxy-O3-phosphono-D-fructosyl)-glycine
-
 ?
ATP + N2-(1-deoxy-D-fructosyl)-glycine
-
 Homo sapiens ADP + N2-(1-deoxy-O3-phosphono-D-fructosyl)-glycine
-
 ?
ATP + N2-(1-deoxy-D-fructosyl)-glycylglycine
-
 Homo sapiens ADP + N2-(1-deoxy-O3-phosphono-D-fructosyl)-glycylglycine
-
 ?
ATP + N2-(1-deoxy-D-fructosyl)-L-valine
-
 Homo sapiens ADP + N2-(1-deoxy-O3-phosphono-D-fructosyl)-L-valine
-
 ?
ATP + N2-(1-deoxy-D-fructosyl)-valine
-
 Mus musculus ADP + N2-(1-deoxy-O3-phosphono-D-fructosyl)-valine
-
 ?
ATP + N2-(1-deoxy-D-fructosyl)-valine
-
 Homo sapiens ADP + N2-(1-deoxy-O3-phosphono-D-fructosyl)-valine
-
 ?
ATP + N6-(1-deoxy-D-fructosyl)-L-lysine
-
 Homo sapiens ADP + N6-(1-deoxy-O3-phosphono-D-fructosyl)-L-lysine
-
 ?
ATP + N6-(1-deoxy-D-fructosyl)-lysine displays about 10times less affinity than for 1-deoxy-1-morpholin-4-yl-D-fructose Mus musculus ADP + N6-(1-deoxy-O3-phosphono-D-fructosyl)-lysine
-
 ?
ATP + N6-(1-deoxy-D-fructosyl)-lysine displays about 10times less affinity than for 1-deoxy-1-morpholin-4-yl-D-fructose Homo sapiens ADP + N6-(1-deoxy-O3-phosphono-D-fructosyl)-lysine
-
 ?
ATP + [protein]-N6-D-fructosyl-L-lysine the physiological function of fructosamine-3-kinase may be to initiate a process leading to the deglycation of fructoselysine and of glycated proteins Mus musculus ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
 ?
ATP + [protein]-N6-D-fructosyl-L-lysine the physiological function of fructosamine-3-kinase may be to initiate a process leading to the deglycation of fructoselysine and of glycated proteins Homo sapiens ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
 ?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Mus musculus
? x * 35000, SDS-PAGE Homo sapiens
? x * 35032, calculated from sequence Mus musculus
? x * 35032, calculated from sequence Homo sapiens
? x * 35171, calculated from sequence Homo sapiens

Synonyms

Synonyms Comment Organism
FN3K
-
 Mus musculus
FN3K
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Mus musculus
7.8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function the physiological function of fructosamine-3-kinase may be to initiate a process leading to the deglycation of fructoselysine and of glycated proteins Mus musculus
physiological function the physiological function of fructosamine-3-kinase may be to initiate a process leading to the deglycation of fructoselysine and of glycated proteins Homo sapiens