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Literature summary for 2.7.1.172 extracted from

  • Collard, F.; Delpierre, G.; Stroobant, V.; Matthijs, G.; van Schaftingen, E.
    A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines (2004), Diabetes, 52, 2888-2895.
    View publication on PubMed
Search for more literature for 2.7.1.172

Cloned(Commentary)

Cloned (Comment) Organism
human FN3K-RP is transfected in human embryonic kidney cells and expressed Homo sapiens
human FN3K-RP is transfected in human embryonic kidney cells and expressed Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-deoxy-1-morpholin-4-yl-D-psicose
-
 Homo sapiens
1-deoxy-1-morpholin-4-yl-D-ribulose
-
 Homo sapiens
N6-D-psicosyl-L-lysine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0035
-
 1-deoxy-1-morpholin-4-yl-D-ribulose pH 7.8, 30°C Homo sapiens
0.16
-
 1-deoxy-1-morpholin-4-yl-D-psicose pH 7.8, 30°C Homo sapiens
0.27
-
 N6-D-psicosyl-L-lysine pH 7.8, 30°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34412
-
 x * 34412, calculated from sequence Homo sapiens
34440
-
 x * 34440, calculated from sequence Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-N6-D-psicosyl-L-lysine Homo sapiens ketosamine-3-kinase 2 plays a role in freeing proteins from ribulosamines or psicosamines, which might arise in a several step process, from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by fructosamine-3-kinase (ketosamine-3-kinase 1), which has, in addition, the unique capacity to phosphorylate fructosamines ADP + [protein]-N6-(O3-phosphono-D-psicosyl)-L-lysine
-
 ?
ATP + [protein]-N6-D-ribulosyl-L-lysine Homo sapiens ketosamine-3-kinase 2 plays a role in freeing proteins from ribulosamines or psicosamines, which might arise in a several step process, from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by fructosamine-3-kinase (ketosamine-3-kinase 1), which has, in addition, the unique capacity to phosphorylate fructosamines ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HA64
-
-
Mus musculus Q8K274
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme, partially purified by chromatography on Blue Sepharose Homo sapiens
recombinant enzyme, partially purified by chromatography on Blue Sepharose Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow highest levels of expression in bone marrow, brain, spleen, kidney, and lens Mus musculus
-
brain highest levels of expression in bone marrow, brain, spleen, kidney, and lens Mus musculus
-
heart expressed at low levels Mus musculus
-
kidney highest levels of expression in bone marrow, brain, spleen, kidney, and lens Mus musculus
-
lens highest levels of expression in bone marrow, brain, spleen, kidney, and lens Mus musculus
-
liver expressed at low levels Mus musculus
-
lung
-
 Mus musculus
-
additional information no expression is observed in the intestinal mucosa Mus musculus
-
skeletal muscle expressed at low levels Mus musculus
-
spleen highest levels of expression in bone marrow, brain, spleen, kidney, and lens Mus musculus
-
testis
-
 Mus musculus
-
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-deoxy-1-morpholin-4-yl-D-psicose
-
 Homo sapiens ADP + 1-deoxy-1-morpholin-4-yl-3-O-phosphono-D-psicose
-
 ?
ATP + 1-deoxy-1-morpholin-4-yl-D-ribulose
-
 Homo sapiens ADP + 1-deoxy-1-morpholin-4-yl-3-O-phosphono-D-ribulose
-
 ?
ATP + N6-D-psicosyl-L-lysine
-
 Homo sapiens ADP + N6-(O3-phosphono-D-psicosyl)-L-lysine
-
 ?
ATP + [protein]-N6-D-psicosyl-L-lysine
-
 Homo sapiens ADP + [protein]-N6-(O3-phosphono-D-psicosyl)-L-lysine
-
 ?
ATP + [protein]-N6-D-psicosyl-L-lysine ketosamine-3-kinase 2 plays a role in freeing proteins from ribulosamines or psicosamines, which might arise in a several step process, from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by fructosamine-3-kinase (ketosamine-3-kinase 1), which has, in addition, the unique capacity to phosphorylate fructosamines Homo sapiens ADP + [protein]-N6-(O3-phosphono-D-psicosyl)-L-lysine
-
 ?
ATP + [protein]-N6-D-ribulosyl-L-lysine
-
 Homo sapiens ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
-
 ?
ATP + [protein]-N6-D-ribulosyl-L-lysine ketosamine-3-kinase 2 plays a role in freeing proteins from ribulosamines or psicosamines, which might arise in a several step process, from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by fructosamine-3-kinase (ketosamine-3-kinase 1), which has, in addition, the unique capacity to phosphorylate fructosamines Homo sapiens ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
-
 ?
additional information FN3K-RP does not phosphorylate fructoselysine, 1-deoxy-1-morpholin-4-yl-D-fructose, or lysozyme glycated with glucose Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 34412, calculated from sequence Homo sapiens
? x * 34440, calculated from sequence Mus musculus

Synonyms

Synonyms Comment Organism
FN3K-related protein
-
 Homo sapiens
FN3K-related protein
-
 Mus musculus
FN3K-RP
-
 Homo sapiens
FN3K-RP
-
 Mus musculus
fructosamine-3-kinase-related protein
-
 Homo sapiens
fructosamine-3-kinase–related protein
-
 Mus musculus
ketosamine 3-kinase 2
-
 Homo sapiens
ketosamine 3-kinase 2
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0064
-
 pH 7.8, 30°C, phosphorylation of lysozyme glycated with allose Homo sapiens 1-deoxy-1-morpholin-4-yl-D-ribulose
0.48
-
 pH 7.8, 30°C, phosphorylation of lysozyme glycated with allose Homo sapiens N6-D-psicosyl-L-lysine
0.58
-
 pH 7.8, 30°C, phosphorylation of lysozyme glycated with allose Homo sapiens 1-deoxy-1-morpholin-4-yl-D-psicose