Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Thermoplasma acidophilum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.097 | - |
(R)-mevalonate | pH 8.5, 55°C | Thermoplasma acidophilum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-mevalonate | Thermoplasma acidophilum | mevalonate-3-kinase and mevalonate-3-phosphate-5-kinase act sequentially in a putative alternate mevalonate pathway in Thermoplasma acidophilum | ADP + (R)-3-phosphomevalonate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermoplasma acidophilum | Q9HIN1 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Thermoplasma acidophilum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-mevalonate | - |
Thermoplasma acidophilum | ADP + (R)-3-phosphomevalonate | - |
? | |
ATP + (R)-mevalonate | mevalonate-3-kinase and mevalonate-3-phosphate-5-kinase act sequentially in a putative alternate mevalonate pathway in Thermoplasma acidophilum | Thermoplasma acidophilum | ADP + (R)-3-phosphomevalonate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ta1305 | locus name | Thermoplasma acidophilum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
55 | - |
- |
Thermoplasma acidophilum |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | 60 | 40°C: about 55% of maximal activity, 60°C: about 95% of maximal activity | Thermoplasma acidophilum |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
1 h, enzyme retains more than 95% of its activity | Thermoplasma acidophilum |
70 | - |
1 h, about 75% loss of activity | Thermoplasma acidophilum |
75 | - |
1 h, complete loss of activity | Thermoplasma acidophilum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5 | - |
(R)-mevalonate | pH 8.5, 55°C | Thermoplasma acidophilum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Thermoplasma acidophilum |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 9.5 | pH 7.0: about 75% of maximal activity, pH 9.5: about 85% of maximal activity | Thermoplasma acidophilum |
General Information | Comment | Organism |
---|---|---|
physiological function | mevalonate-3-kinase and mevalonate-3-phosphate-5-kinase act sequentially in a putative alternate mevalonate pathway in Thermoplasma acidophilum | Thermoplasma acidophilum |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
51.5 | - |
(R)-mevalonate | pH 8.5, 55°C | Thermoplasma acidophilum |