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Literature summary for 2.7.1.188 extracted from

  • Zhang, C.S.; Stratmann, A.; Block, O.; Brückner, R.; Podeschwa, M.; Altenbach, H.J.; Wehmeier, U.F.; Piepersberg, W.
    Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-Phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway (2002), J. Biol. Chem., 277, 22853-22862.
    View publication on PubMed
Search for more literature for 2.7.1.188

Cloned(Commentary)

Cloned (Comment) Organism
expressed in strains of Streptomyces lividans 66 strains 1326, TK23, and TK64 Actinoplanes sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2-epi-5-epi-valiolone Actinoplanes sp. the enzyme is involved in the biosynthesis of acarbose ADP + 2-epi-5-epi-valiolone 7-phosphate
-
 ?
ATP + 2-epi-5-epi-valiolone Actinoplanes sp. 50/110 the enzyme is involved in the biosynthesis of acarbose ADP + 2-epi-5-epi-valiolone 7-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Actinoplanes sp. Q8RIS8
-
-
Actinoplanes sp. 50/110 Q8RIS8
-
-

Purification (Commentary)

Purification (Comment) Organism
His-tagged AcbM protein Actinoplanes sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-epi-2-epi-5-epi-valiolol
-
 Actinoplanes sp. ?
-
 ?
ATP + 1-epi-2-epi-5-epi-valiolol
-
 Actinoplanes sp. 50/110 ?
-
 ?
ATP + 2-epi-5-epi-valiolol
-
 Actinoplanes sp. ?
-
 ?
ATP + 2-epi-5-epi-valiolol
-
 Actinoplanes sp. 50/110 ?
-
 ?
ATP + 2-epi-5-epi-valiolone
-
 Actinoplanes sp. ADP + 2-epi-5-epi-valiolone 7-phosphate
-
 ?
ATP + 2-epi-5-epi-valiolone the enzyme is involved in the biosynthesis of acarbose Actinoplanes sp. ADP + 2-epi-5-epi-valiolone 7-phosphate
-
 ?
ATP + 2-epi-5-epi-valiolone
-
 Actinoplanes sp. 50/110 ADP + 2-epi-5-epi-valiolone 7-phosphate
-
 ?
ATP + 2-epi-5-epi-valiolone the enzyme is involved in the biosynthesis of acarbose Actinoplanes sp. 50/110 ADP + 2-epi-5-epi-valiolone 7-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AcbM
-
 Actinoplanes sp.

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of acarbose Actinoplanes sp.