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Literature summary for 2.7.1.2 extracted from
- Glucokinase of Dictyostelium discoideum (1969), Biochemistry, 8, 5011-5015.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Dictyostelium discoideum |  |
| D-glucose 6-phosphate | competitive inhibitor to glucose and noncompetitive to ATP | Dictyostelium discoideum | |
| additional information | not: glucose or ATP up to 15 mM, mannose, fructose, 2-deoxyglucose, GDP, IDP, CDP, UDP, adenosine monophosphate, deoxyadenosine monophosphate, 3',5'-adenosine monophosphate, inorganic phosphate | Dictyostelium discoideum |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.12 | - |
D-glucose | 20°C pH 7 | Dictyostelium discoideum | |
| 1.1 | - |
ATP | 20°C pH 7 | Dictyostelium discoideum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | completely dependent on presence of Mg2+ | Dictyostelium discoideum | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-glucose | Dictyostelium discoideum | - |
ADP + D-glucose 6-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dictyostelium discoideum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Dictyostelium discoideum |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.51 | - |
- |
Dictyostelium discoideum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-glucose | - |
Dictyostelium discoideum | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | highly specific for D-glucose | Dictyostelium discoideum | ADP + D-glucose 6-phosphate | - |
? | |
| additional information | not: mannose, fructose, 2-deoxyglucose, UTP, ITP, GTP | Dictyostelium discoideum | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | - |
assay at | Dictyostelium discoideum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Dictyostelium discoideum |
| 7.5 | - |
- |
Dictyostelium discoideum |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | pH 6.0: about 55% of activity maximum, pH 9.0: about 75% of activity maximum | Dictyostelium discoideum |
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