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Literature summary for 2.7.1.20 extracted from
- Kinetic studies of rat liver adenosine kinase. Explanation of exchange reaction between adenosine and AMP (1994), J. Biol. Chem., 269, 17820-17825.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | product inhibition | Rattus norvegicus |  |
| AMP | product inhibition | Rattus norvegicus | |
| EDTA | at 100 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic study | Rattus norvegicus | |
| 0.00012 | - |
adenosine | pH 7.2, 37ºC | Rattus norvegicus | |
| 0.00015 | 0.0005 | adenosine | pH 7.2, 37ºC | Rattus norvegicus | |
| 0.003 | - |
ADP | pH 7.2, 37ºC | Rattus norvegicus | |
| 0.014 | - |
MgATP2- | pH 7.2, 37ºC | Rattus norvegicus | |
| 0.016 | - |
AMP | pH 7.2, 37ºC | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activation | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male, Wistar strain | - |
| Rattus norvegicus Wistar | - |
male, Wistar strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + adenosine = ADP + AMP | mechanism | Rattus norvegicus | |
| ATP + adenosine = ADP + AMP | ordered bi bi mechanism | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 2'-deoxy-adenosine | - |
Rattus norvegicus | ADP + 2'-deoxy-AMP | - |
? | |
| ATP + 2'-deoxy-adenosine | - |
Rattus norvegicus Wistar | ADP + 2'-deoxy-AMP | - |
? | |
| ATP + adenosine | - |
Rattus norvegicus | ADP + AMP | - |
? | |
| ATP + adenosine | - |
Rattus norvegicus Wistar | ADP + AMP | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.011 | - |
ADP | pH 7.2, 37ºC, with variable MgATP2- and constant adenosine concentrations | Rattus norvegicus | |
| 0.16 | - |
AMP | pH 7.2, 37ºC, with constant MgATP2- and variable adenosine concentrations | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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