Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.21 extracted from

  • Bone, R.; Cheng, Y.C.; Wolfenden, R.
    Inhibition of thymidine kinase by P1-(adenosine-5)-P5-(thymidine-5)-pentaphosphate (1986), J. Biol. Chem., 261, 5731-5735.
    View publication on PubMed
Search for more literature for 2.7.1.21

Inhibitors

Inhibitors Comment Organism Structure
additional information bisubstrate analogs with adenosine and thymidine joined at their 5' positions by polyphorphoryl linkages of varying lengths can serve as inhibitors Homo sapiens
P1-(Adenosine-5')-P3-(thymidine-5')-triphosphate
-
 Homo sapiens
P1-(adenosine-5')-P4-(thymidine-5')-tetraphosphate
-
 Homo sapiens
P1-(Adenosine-5')-P5-(thymidine-5')-pentaphosphate
-
 Homo sapiens
P1-(Adenosine-5')-P6-(thymidine-5')-hexaphosphate
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0026
-
 thymidine mitochondrial enzyme, pH 7.5, 37°C Homo sapiens
0.01
-
 thymidine cytosolic enzyme, pH 7.5, 37°C Homo sapiens
0.07
-
 ATP cytosolic enzyme, pH 7.5, 37°C Homo sapiens
0.11
-
 ATP mitochondrial enzyme, pH 7.5, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blast cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + thymidine
-
 Homo sapiens ADP + dTMP
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information bisubstrate analogs with adenosine and thymidine joined at their 5' positions by polyphorphoryl linkages of varying lengths Homo sapiens