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Literature summary for 2.7.1.21 extracted from

  • Ellims, P.H.; van der Weyden, M.B.
    Kinetic mechanism and inhibition of human liver thymidine kinase (1981), Biochim. Biophys. Acta, 660, 238-242.
    View publication on PubMed
Search for more literature for 2.7.1.21

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
 Homo sapiens
additional information overview: purine nucleotides, pyrimidine nucleotides Homo sapiens
TMP
-
 Homo sapiens
TTP
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 thymidine pH 7.4, 37°C Homo sapiens
0.006
-
 deoxycytidine pH 7.4, 37°C Homo sapiens
0.09
-
 ATP pH 7.4, 37°C Homo sapiens
0.15
-
 CTP pH 7.4, 37°C Homo sapiens
0.26
-
 UTP pH 7.4, 37°C Homo sapiens
0.3
-
 GTP pH 7.4, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mn2+ can partially substitute for Mg2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + thymidine ATP can be substituted by UTP Homo sapiens ADP + dTMP
-
 ?
CTP + thymidine
-
 Homo sapiens CDP + thymidine 5'-phosphate
-
 ?
GTP + thymidine
-
 Homo sapiens GDP + thymidine 5'-phosphate
-
 ?
UTP + thymidine
-
 Homo sapiens UDP + dTMP
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0085
-
 TTP competitive to ATP, pH 7.4, 37°C Homo sapiens
0.0135
-
 TTP competitive to thymidine, pH 7.4, 37°C Homo sapiens
0.63
-
 TMP pH 7.4, 37°C Homo sapiens
6.5
-
 ADP pH 7.4, 37°C Homo sapiens