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Literature summary for 2.7.1.21 extracted from

  • Iqbal, J.; Scapozza, L.; Folkers, G.; Mueller, C.E.
    Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors (2007), J. Chromatogr. B, 846, 281-290.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aciclovir competitive inhibitor Herpes simplex virus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
aciclovir monophosphate
-
Herpes simplex virus
0.12
-
ganciclovir monophosphate
-
Herpes simplex virus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Herpes simplex virus

Organism

Organism UniProt Comment Textmining
Herpes simplex virus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
-
Herpes simplex virus ?
-
?
ATP + aciclovir monophosphate
-
Herpes simplex virus ?
-
?
ATP + ganciclovir monophosphate
-
Herpes simplex virus ?
-
?

Synonyms

Synonyms Comment Organism
HSV-1 TK
-
Herpes simplex virus
type 1 thymidine kinase
-
Herpes simplex virus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0253
-
(E)-5-(2-bromovinyl)-2'-deoxyuridine determined by capillary electrophoresis method Herpes simplex virus
0.0272
-
ganciclovir monophosphate determined by capillary electrophoresis method Herpes simplex virus
0.238
-
aciclovir monophosphate determined by capillary electrophoresis method Herpes simplex virus