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Literature summary for 2.7.1.21 extracted from

  • Munch-Petersen, B.
    Enzymatic regulation of cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2: a mini review (2010), Nucleosides Nucleotides Nucleic Acids, 29, 363-369.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
H121N the mutant has less than 7% kinase activity compared to the wild type enzyme Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol thymidine kinase 1 Mus musculus 5829
-
mitochondrion thymidine kinase 2 Mus musculus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
2 * 25000, isoform TK1, SDS-PAGE Mus musculus
25500
-
2 * 25500, isoform TK1, calculated from amino acid sequence Mus musculus
60000
-
isoform TK1, gel filtration Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + thymidine
-
Mus musculus ADP + dTMP
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 25000, isoform TK1, SDS-PAGE Mus musculus
homodimer 2 * 25500, isoform TK1, calculated from amino acid sequence Mus musculus
monomer or dimer isoform TK2 Mus musculus

Synonyms

Synonyms Comment Organism
thymidine kinase 1
-
Mus musculus
thymidine kinase 2
-
Mus musculus
TK1
-
Mus musculus
TK2
-
Mus musculus

General Information

General Information Comment Organism
malfunction isoform TK2-deficient animal show growth retardation and premature death Mus musculus