Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2 | Rattus norvegicus | |
3'-azido-3'-deoxythymidine | stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2 | Homo sapiens | |
3'-deoxy-3'-fluorothymidine | stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2 | Homo sapiens | |
3'-fluorothymidine | stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2 | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | inhibits thymidine phosphorylation catalyzed by thymidine kinase 2 | Homo sapiens | |
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | inhibits thymidine phosphorylation catalyzed by thymidine kinase 2 | Rattus norvegicus | |
3'-deoxy-3'-fluorothymidine | inhibits thymidine phosphorylation catalyzed by thymidine kinase 2 | Homo sapiens | |
3'-fluorothymidine | inhibits thymidine phosphorylation catalyzed by thymidine kinase 2 | Rattus norvegicus | |
additional information | at physiological relevant concentration deoxycytidine phosphorylation is not inhibited by 3-azido-3'-deoxythmidine or 3'-fluorothymidine | Homo sapiens | |
additional information | at physiological relevant concentration deoxycytidine phosphorylation is not inhibited by 3'-azido-3'-deoxythmidine or 3'-fluorothymidine | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0188 | - |
thymidine | pH and temperature not specified in the publication | Rattus norvegicus | |
0.0414 | - |
deoxycytidine | pH and temperature not specified in the publication | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
DEAE-Sephadex gel filtration | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxycytidine | - |
Homo sapiens | ADP + dCMP | - |
? | |
ATP + deoxycytidine | - |
Rattus norvegicus | ADP + dCMP | - |
? | |
ATP + thymidine | - |
Homo sapiens | ADP + dTMP | - |
? | |
ATP + thymidine | - |
Rattus norvegicus | ADP + dTMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thymidine kinase 2 | - |
Homo sapiens |
thymidine kinase 2 | - |
Rattus norvegicus |
TK2 | - |
Homo sapiens |
TK2 | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0014 | - |
3'-deoxy-3'-fluorothymidine | pH and temperature not specified in the publication | Homo sapiens | |
0.0014 | - |
3'-fluorothymidine | pH and temperature not specified in the publication | Rattus norvegicus | |
0.0039 | - |
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | pH and temperature not specified in the publication | Homo sapiens | |
0.0039 | - |
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | pH and temperature not specified in the publication | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | thymidine kinase 2 plays an important role in providing precursors for the replication and maintenance of mitochondrial DNA, especially in nonproliferating cells | Homo sapiens |
physiological function | thymidine kinase 2 plays an important role in providing precursors for the replication and maintenance of mitochondrial DNA, especially in nonproliferating cells | Rattus norvegicus |