Literature summary for 2.7.1.210 extracted from

Huang, H.; Carter, M.S.; Vetting, M.W.; Al-Obaidi, N.; Patskovsky, Y.; Almo, S.C.; Gerlt, J.A.
A general strategy for the discovery of metabolic pathways: D-threitol, L-threitol, and erythritol utilization in Mycobacterium smegmatis (2015), J. Am. Chem. Soc., 137, 14570-14573.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0046	-	D-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
0.339	-	dihydroxyacetone	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
0.396	-	D-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + D-erythrulose	Mycolicibacterium smegmatis	the enzyme participates in the degradation of erythritol and D-threitol	ADP + D-erythrulose 4-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycolicibacterium smegmatis	A0QXE4	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-erythrulose	-	Mycolicibacterium smegmatis	ADP + D-erythrulose 4-phosphate	-	?
ATP + D-erythrulose	the enzyme participates in the degradation of erythritol and D-threitol	Mycolicibacterium smegmatis	ADP + D-erythrulose 4-phosphate	-	?
ATP + dihydroxyacetone	catalytic efficiency is about 3500fold lower compared to D-erythrulose	Mycolicibacterium smegmatis	ADP + ?	-	?
ATP + L-erythrulose	catalytic efficiency is about 3000fold lower compared to D-erythrulose	Mycolicibacterium smegmatis	ADP + L-erythrulose 4-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
derK	-	Mycolicibacterium smegmatis

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.063	-	dihydroxyacetone	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
0.091	-	D-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
2.88	-	D-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis

General Information

General Information	Comment	Organism
metabolism	the enzyme participates in the degradation of erythritol and D-threitol	Mycolicibacterium smegmatis

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
0.186	-	dihydroxyacetone	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
0.23	-	D-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
626	-	D-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis

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Release 2023.1 (January 2023)