Literature summary for 2.7.1.33 extracted from

Hong, B.S.; Senisterra, G.; Rabeh, W.M.; Vedadi, M.; Leonardi, R.; Zhang, Y.M.; Rock, C.O.; Jackowski, S.; Park, H.W.
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder (2007), J. Biol. Chem., 282, 27984-27993.

Search for more literature for 2.7.1.33

Cloned(Commentary)

Cloned (Comment)	Organism
expression as a His-tagged fusion protein in Escherichia coli	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop vapor diffusion method at 18°C, homodimeric structures of the catalytic core of PanK1alpha in complex with acetyl-CoA. Crystallographic mapping of missense mutations associated with pantothenate kinase-associated neurodegeneration disease	Homo sapiens
sitting drop vapor diffusion method at 18°C, homodimeric structures of the catalytic core of PanK3 in complex with acetyl-CoA. Crystallographic mapping of missense mutations associated with pantothenate kinase-associated neurodegeneration disease	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
acetyl-CoA	a feedback inhibitor; a feedback inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + pantothenate	Homo sapiens	pantothenate kinase catalyzes the first step in CoA biosynthesis	ADP + 4'-phosphopantothenate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8TE04	-	-
Homo sapiens	Q9H999	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-pantothenate	-	Homo sapiens	ADP + 4'-phosphopantothenate	-	?
ATP + pantothenate	pantothenate kinase catalyzes the first step in CoA biosynthesis	Homo sapiens	ADP + 4'-phosphopantothenate	-	?

Synonyms

Synonyms	Comment	Organism
PanK1alpha	-	Homo sapiens
PanK3	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)