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Literature summary for 2.7.1.33 extracted from

  • Rowan, A.S.; Nicely, N.I.; Cochrane, N.; Wlassoff, W.A.; Claiborne, A.; Hamilton, C.J.
    Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase (2009), Org. Biomol. Chem., 7, 4029-4036.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.33

Cloned(Commentary)

Cloned (Comment) Organism
-
 Bacillus anthracis

Inhibitors

Inhibitors Comment Organism Structure
5'-deoxy-5'-(4-(beta-D-galactopyranosyloxymethyl)-1,2,3-triazol-1-yl)adenosine competitive inhibitor with respect to ATP Bacillus anthracis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.117
-
 dGTP
-
 Bacillus anthracis
0.138
-
 dATP
-
 Bacillus anthracis
0.51
-
 ATP
-
 Bacillus anthracis
0.723
-
 dTTP
-
 Bacillus anthracis
0.839
-
 dCTP
-
 Bacillus anthracis
1.715
-
 UTP
-
 Bacillus anthracis
1.759
-
 CTP
-
 Bacillus anthracis

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bacillus anthracis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pantothenate + ATP
-
 Bacillus anthracis 4'-phosphopantothenate + ADP
-
 ?
pantothenate + CTP
-
 Bacillus anthracis 4'-phosphopantothenate + CDP
-
 ?
pantothenate + dATP
-
 Bacillus anthracis 4'-phosphopantothenate + dADP
-
 ?
pantothenate + dCTP
-
 Bacillus anthracis 4'-phosphopantothenate + dCDP
-
 ?
pantothenate + dGTP
-
 Bacillus anthracis 4'-phosphopantothenate + dGDP
-
 ?
pantothenate + dTTP
-
 Bacillus anthracis 4'-phosphopantothenate + dTDP
-
 ?
pantothenate + UTP
-
 Bacillus anthracis 4'-phosphopantothenate + UDP
-
 ?

Synonyms

Synonyms Comment Organism
pantothenate kinase
-
 Bacillus anthracis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.4
-
 dTTP
-
 Bacillus anthracis
0.5
-
 dCTP
-
 Bacillus anthracis
0.8
-
 dGTP
-
 Bacillus anthracis
0.9
-
 dATP
-
 Bacillus anthracis
1.5
-
 ATP
-
 Bacillus anthracis
1.5
-
 CTP
-
 Bacillus anthracis
1.7
-
 UTP
-
 Bacillus anthracis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.164
-
 5'-deoxy-5'-(4-(beta-D-galactopyranosyloxymethyl)-1,2,3-triazol-1-yl)adenosine
-
 Bacillus anthracis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.5
-
 dTTP
-
 Bacillus anthracis
0.6
-
 dCTP
-
 Bacillus anthracis
0.9
-
 CTP
-
 Bacillus anthracis
1
-
 UTP
-
 Bacillus anthracis
2.9
-
 ATP
-
 Bacillus anthracis
6.5
-
 dGTP
-
 Bacillus anthracis
6.6
-
 dATP
-
 Bacillus anthracis