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Literature summary for 2.7.1.35 extracted from

  • Takeuchi, F.; Tsubouchi, R.; Shibata, Y.
    Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro (1985), Biochem. J., 227, 537-544.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
NAD+ 0.5 mM, activation to 125%, activity with pyridoxine Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
5-hydroxytryptamine 0.5 mM, 11% inhibition of activity with pyridoxine, 81% inhibition of activity with pyridoxal Rattus norvegicus
NADH 0.5 mM, 14% inhibition of activity with pyridoxine, 11% inhibition of activity with pyridoxal Rattus norvegicus
picolinate 0.5 mM, 95% inhibition of activity with pyridoxine, 97% inhibition of activity with pyridoxal Rattus norvegicus
pyridoxine substrate inhibition above 0.2 mM Rattus norvegicus
quinolinate 0.5 mM, 82% inhibition of activity with pyridoxine, 82% inhibition of activity with pyridoxal Rattus norvegicus
tryptamine no inhibition of activity with pyridoxine, 72% inhibition of activity with pyridoxal Rattus norvegicus
xanthurenate 0.5 mM, 19% inhibition of activity with pyridoxine, 18% inhibition of activity with pyridoxal Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
pyridoxine 37°C Rattus norvegicus
0.19
-
pyridoxal 37°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.27
-
reaction with pyridoxal Rattus norvegicus
1.42
-
reaction with pyridoxine Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyridoxal
-
Rattus norvegicus ADP + pyridoxal 5'-phosphate
-
?
ATP + pyridoxine
-
Rattus norvegicus ADP + pyridoxine 5'-phosphate
-
?