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Literature summary for 2.7.1.35 extracted from

  • Tang, L.; Li, M.H.; Cao, P.; Wang, F.; Chang, W.R.; Bach, S.; Reinhardt, J.; Ferandin, Y.; Galons, H.; Wan, Y.; Gray, N.; Meijer, L.; Jiang, T.; Liang, D.C.
    Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives (2005), J. Biol. Chem., 280, 31220-31229.
    View publication on PubMed
Search for more literature for 2.7.1.35

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, in complex with (R)-roscovitine and N6-methyl-(R)-roscovitine Ovis aries

Inhibitors

Inhibitors Comment Organism Structure
(R)-roscovitine binds to the pyridoxal binding site Ovis aries

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyridoxal Ovis aries generates the active form of vitamin B6, which serves as cofactor for many enzymes ADP + pyridoxal 5'-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Ovis aries P82197
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyridoxal
-
 Ovis aries ADP + pyridoxal 5'-phosphate
-
 ?
ATP + pyridoxal generates the active form of vitamin B6, which serves as cofactor for many enzymes Ovis aries ADP + pyridoxal 5'-phosphate
-
 ?
ATP + pyridoxamine
-
 Ovis aries ADP + pyridoxamine 5'-phosphate
-
 ?
ATP + pyridoxine
-
 Ovis aries ADP + pyridoxine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PdxK
-
 Ovis aries