Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3-dimethylallyl diphosphate | - |
Homo sapiens | |
dolichol phosphate | - |
Homo sapiens | |
farnesol | - |
Homo sapiens | |
farnesyl diphosphate | - |
Homo sapiens | |
geranyl diphosphate | - |
Homo sapiens | |
geranylgeranyl diphosphate | - |
Homo sapiens | |
isopentenyl diphosphate | - |
Homo sapiens | |
additional information | not inhibited by R-mevalonate 5-diphosphate, geraniol and dolichol up to 0.084, 0.226 and 0.68 mM, respectively | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.15 | - |
(R,S)-mevalonate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
0.44 | - |
ATP | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42500 | - |
x * 42500, recombinant mevalonate kinase, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + mevalonate | Homo sapiens | part of the cholesterol and nonsterol isoprene biosynthetic pathway | ADP + phosphomevalonate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant mevalonat kinase-glutathione S-transferase fusion protein, glutathione Sepharose beads | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + mevalonate | - |
Homo sapiens | ADP + phosphomevalonate | - |
? | |
ATP + mevalonate | part of the cholesterol and nonsterol isoprene biosynthetic pathway | Homo sapiens | ADP + phosphomevalonate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 42500, recombinant mevalonate kinase, SDS-PAGE | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000104 | - |
farnesyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
0.016 | - |
isopentenyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
0.02 | - |
3,3-dimethylallyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
0.059 | - |
geranylgeranyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
0.072 | - |
farnesol | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
0.083 | - |
dolichol phosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
0.116 | - |
geranyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens |