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Literature summary for 2.7.1.36 extracted from

  • Cho, Y.K.; Rios, S.E.; Kim, J.J.; Miziorko, H.M.
    Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease (2001), J. Biol. Chem., 276, 12573-12578.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
S145A 37% of wild-type activity Homo sapiens
S146A 0.02% of wild-type activity Homo sapiens
S201A 200% of wild-type activity Homo sapiens
T243A 39% of wild-type activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.15
-
ATP pH 7.5, 30°C, recombinant S145A mutant mevalonate kinase Homo sapiens
0.253
-
mevalonate pH 7.5, 30°C, recombinant S145A mevalonate kinase Homo sapiens
0.38
-
ATP pH 7.5, 30°C, recombinant T243A mevalonate kinase Homo sapiens
0.41
-
ATP pH 7.5, 30°C, recombinant S146A mevalonate kinase Homo sapiens
0.47
-
mevalonate pH 7.5, 30°C, recombinant T243A mevalonate kinase Homo sapiens
0.51
-
mevalonate pH 7.5, 30°C, recombinant S146A mevalonate kinase Homo sapiens
0.51
-
ATP pH 7.5, 30°C, recombinant S201A mevalonate kinase Homo sapiens
2.5
-
mevalonate pH 7.5, 30°C, recombinant S201A mevalonate kinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + mevalonate
-
Homo sapiens ADP + phosphomevalonate
-
?

Subunits

Subunits Comment Organism
?
-
Homo sapiens