Activating Compound | Comment | Organism | Structure |
---|---|---|---|
atorvastatin | besides increases in mRNA level of HMG CoA reductase, treatment increases hepatic mRNA levels of both mevalonate kinase and cob(I)alamin adenosyltransferase | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
heart | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
liver | highest expression of both mevalonate kinase and cob(I)alamin adenosyltransferase | Mus musculus | - |
liver | highest expression of both mevalonate kinase and cob(I)alamin adenosyltransferase | Homo sapiens | - |
additional information | mevalonate kinase and cob(I)alamin adenosyltransferase display a similar tissue expression pattern. Their genes are located in a head-to-head formation and are suppressed by an excess of cholesterol as well as sterol regulatory element binding protein SREBP-2 | Mus musculus | - |
additional information | mevalonate kinase and cob(I)alamin adenosyltransferase display a similar tissue expression pattern. Their genes are located in a head-to-head formation and are suppressed by an excess of cholesterol as well as sterol regulatory element binding protein SREBP-2 | Homo sapiens | - |