Application | Comment | Organism |
---|---|---|
medicine | inhibition of HMG-CoA reductase by simvastatin treatment of LPS-stimulated peripheral blood mononuclear cells mimicks mevalonate kinase deficiency and results in increased interleukin-1beta secretion in Rac1/phosphatidylinositol-3 kinase-dependent manner. Results suggest that in mevalonate kinase deficiency, dysregulated isoprenoid biosynthesis activates Rac1/phosphatidylinositol-3 kinase/PKB resulting in caspase-1 activation with increased interleukin-1beta processing and release. Inhibition of Rac1 in LPS-stimulated peripheral blood mononuclear cells from patients with mevalonate kinase deficiency results in dramatic reduction in interleukin-1beta release | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mononuclear cell | LPS-stimulated peripheral blood mononuclear cell | Homo sapiens | - |