Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of one mevalonate kinase allele yields viable mice with significantly reduced liver mevalonate kinase enzyme activity. Cholesterol levels in tissues and blood, and isoprene end-products ubiquinone and dolichol in tissues are normal in Mvk+/- mice. Mevalonate concentrations are increased in spleen, heart, and kidney yet normal in brain and liver. While the trend is for higher IgA levels in Mvk+/- sera, IgD levels are significantly increased and the animals show increased serum tumor necrosis factor-alpha levels | Mus musculus |
Organism | UniProt | Comment | Textmining |
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Mus musculus | - |
murine model of hyper-IgD syndrome | - |